Vasodilatory responses of renal interlobular arteries to epoxyeicosatrienoic acids analog are not enhanced in ren-2 transgenic hypertensive rats: Evidence against a role of direct vascular effects of epoxyeicosatrienoic acids in progression of experimental heart failure

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F17%3A00060308" target="_blank" >RIV/00023001:_____/17:00060308 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/17:10373901

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/66/66_29.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/66/66_29.pdf</a>

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Vasodilatory responses of renal interlobular arteries to epoxyeicosatrienoic acids analog are not enhanced in ren-2 transgenic hypertensive rats: Evidence against a role of direct vascular effects of epoxyeicosatrienoic acids in progression of experimental heart failure

Original language description

Pathophysiological mechanisms underlying the development of renal dysfunction and progression of congestive heart failure (CHF) remain poorly understood. Recent studies have revealed striking differences in the role of epoxyeicosatrienoic acids (EETs), active products of cytochrome P-450-dependent epoxygenase pathway of arachidonic acid, in the progression of aorto-caval fistula (ACF)-induced CHF between hypertensive Ren-2 renin transgenic rats (TGR) and transgene-negative normotensive Hannover Sprague-Dawley (HanSD) controls. Both ACF TGR and ACF HanSD strains exhibited marked intrarenal EETs deficiency and impairment of renal function, and in both strains chronic pharmacologic inhibition of soluble epoxide hydrolase (sEH) (which normally degrades EETs) normalized EETs levels. However, the treatment improved the survival rate and attenuated renal function impairment in ACF TGR only. Here we aimed to establish if the reported improved renal function and attenuation of progression of CHF in ACF TGR observed after sEH blockade depends on increased vasodilatory responsiveness of renal resistance arteries to EETs. Therefore, we examined the responses of interlobar arteries from kidneys of ACF TGR and ACF HanSD rats to EET-A, a new stable 14,15-EET analog. We found that the arteries from ACF HanSD kidneys rats exhibited greater vasodilator responses when compared to the ACF TGR arteries. Hence, reduced renal vasodilatory responsiveness cannot be responsible for the lack of beneficial effects of chronic sEH inhibition on the development of renal dysfunction and progression of CHF in ACF HanSD rats.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

<a href="/en/project/GA15-07544S" target="_blank" >GA15-07544S: Cardioprotective and antihypertensive effects of agonistic epoxyeicosatrienoic acids analogs.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological research

ISSN

0862-8408

e-ISSN

—

Volume of the periodical

66

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

11

Pages from-to

29-39

UT code for WoS article

000398620000003

EID of the result in the Scopus database

—