Inhibition of soluble epoxide hydrolase counteracts the development of renal dysfunction and progression of congestive heart failure in Ren-2 transgenic hypertensive rats with aorto-caval fistula

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10295698" target="_blank" >RIV/00216208:11130/15:10295698 - isvavai.cz</a>

Alternative codes found

RIV/00023001:_____/15:00059550

Result on the web

<a href="http://dx.doi.org/10.1111/1440-1681.12419" target="_blank" >http://dx.doi.org/10.1111/1440-1681.12419</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/1440-1681.12419" target="_blank" >10.1111/1440-1681.12419</a>

Result language

angličtina

Original language name

Inhibition of soluble epoxide hydrolase counteracts the development of renal dysfunction and progression of congestive heart failure in Ren-2 transgenic hypertensive rats with aorto-caval fistula

Original language description

The detailed mechanisms determining the course of congestive heart failure (CHF) in hypertensive subjects with associated renal dysfunction remain unclear. In Ren-2 transgenic rats (TGR), a model of angiotensin II (ANG II)-dependent hypertension, CHF wasinduced by volume overload achieved by creation of the aorto-caval fistula (ACF). In these rats we investigated the putative pathophysiological contribution of epoxyeicosatrienoic acids (EETs) and compared it with the role of the renin-angiotensin system (RAS). We found that untreated ACF TGR exhibited marked intrarenal and myocardial deficiency of EETs and impairment of renal function. Chronic treatment of these rats with cis-4-[4-(3-adamantan-1-yl-ureido)cyclohexyloxy]benzoic acid (c-AUCB, 3mg/L in drinking water), an inhibitor of soluble epoxide hydrolase (sEH) which normally degrades EETs, increased intrarenal and myocardial EETs, markedly improved survival rate, and increased renal blood flow, glomerular filtration rate and fracti

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical and Experimental Pharmacology and Physiology [online]

ISSN

1440-1681

e-ISSN

—

Volume of the periodical

42

Issue of the periodical within the volume

7

Country of publishing house

PK - PAKISTAN

Number of pages

13

Pages from-to

795-807

UT code for WoS article

000357322900010

EID of the result in the Scopus database

2-s2.0-84933566146