Lack of impact of hyperchloremia in brain-dead organ donors on the onset of kidney allograft function in the recipients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F17%3A00075956" target="_blank" >RIV/00023001:_____/17:00075956 - isvavai.cz</a>

Alternative codes found

RIV/00843989:_____/17:E0106486

Result on the web

<a href="http://www.sciencedirect.com/science/article/pii/S0041134517303196?via%3Dihub" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0041134517303196?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.transproceed.2017.02.053" target="_blank" >10.1016/j.transproceed.2017.02.053</a>

Result language

angličtina

Original language name

Lack of impact of hyperchloremia in brain-dead organ donors on the onset of kidney allograft function in the recipients

Original language description

Background. Hyperchloremia produces renal vasoconstriction and fall in glomerular filtration rate. In 90% of brain-dead organ donors, diabetes insipidus develops, characterized by inappropriate diuresis, hyperosmolality, and hyperchloremia. The aim of this study was to determine the relationship between the serum concentration of chlorides of the donor and the onset of the function of the kidney allograft in the recipient. Methods. We retrospectively studied 213 donors and kidney allograft recipients. Serum creatinine concentrations and glomerular filtration rates on the 1st, 7th, and 30th days after transplantation of the recipients from hyperchloremic donors were compared with the recipients from normochloremic donors, as well as the incidences of acute tubular necrosis and delayed graft function. Results. On the 1st day, serum creatinine concentrations of the recipients from hyperchloremic and normochloremic donors, respectively, were 448.2 +/- 212.1 mu mol/L and 502.2 +/- 197.8 mu mol/L (P = .1), on the 7th day, 168.6 +/- 102.6 mu mol/L and 196.9 +/- 120.6 mmol/L (P = .13), and on the 30th day, 129.4 +/- 43.3 mu mol/L and 131.8 43.6 mu mol/L (P = .73). The differences were statistically significant. The groups also did not differ significantly in glomerular filtration rates and incidences of acute tubular necrosis and delayed graft function. Conclusions. In this study, no significant correlation between serum chloride concentrations of the organ donors and the onset of the function of kidney allografts in the recipients was found.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30213 - Transplantation

Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Transplantation proceedings

ISSN

0041-1345

e-ISSN

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Volume of the periodical

49

Issue of the periodical within the volume

6

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

1262-1269

UT code for WoS article

000406734700010

EID of the result in the Scopus database

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