Management of Kidney Transplant Outpatients With COVID-19: A Single Center Experience
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F24%3A10486967" target="_blank" >RIV/00179906:_____/24:10486967 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=pCOvao1H2y" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=pCOvao1H2y</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/ti.2024.12920" target="_blank" >10.3389/ti.2024.12920</a>
Alternative languages
Result language
angličtina
Original language name
Management of Kidney Transplant Outpatients With COVID-19: A Single Center Experience
Original language description
Patients undergoing kidney transplant are at risk of severe COVID-19. Our single-center retrospective analysis evaluated the outcomes of kidney transplant outpatients with COVID-19 who were managed with reduced immunosuppression and treatment with molnupiravir. Between January 2022 and May 2023, we included 93 patients (62 men, average age 56 years), serum creatinine 127 (101-153) mu mol/L. Molnupiravir was administered, and immunosuppressive therapy was reduced immediately following the confirmation of SARS-CoV-2 infection by PCR, which was 2 (1-3) days after the onset of symptoms. Only three (3.2%) patients required hospitalization, and one patient died. Acute kidney injury was observed in two patients. During the follow-up period of 19 (15-22) months, there was no significant increase in proteinuria, no acute or new chronic graft rejection, and kidney graft function remained stable; serum creatinine was 124 (106-159) mu mol/L post-COVID-19 infection and 128 (101-161) mu mol/L at the end of the follow-up period. Our results demonstrate that early initiation of molnupiravir treatment combined with a temporary reduction in immunosuppressive therapy results in favorable clinical outcomes in patients with COVID-19, with preservation of good graft function and no episodes of graft rejection.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30213 - Transplantation
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Transplant International
ISSN
0934-0874
e-ISSN
1432-2277
Volume of the periodical
37
Issue of the periodical within the volume
SEP
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
12920
UT code for WoS article
001328988700001
EID of the result in the Scopus database
2-s2.0-85206053009