Clinical Features, Outcomes, and Response to Corticosteroid Treatment of Acute Tubulointerstitial Nephritis: A Single-Centre Retrospective Cohort Study in the Czech Republic

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F24%3A43926224" target="_blank" >RIV/00064173:_____/24:43926224 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/24:10471972 RIV/00216208:11120/24:43926224 RIV/00064211:_____/24:W0000065 RIV/00064165:_____/24:10471972

Result on the web

<a href="https://doi.org/10.1159/000535415" target="_blank" >https://doi.org/10.1159/000535415</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000535415" target="_blank" >10.1159/000535415</a>

Result language

angličtina

Original language name

Clinical Features, Outcomes, and Response to Corticosteroid Treatment of Acute Tubulointerstitial Nephritis: A Single-Centre Retrospective Cohort Study in the Czech Republic

Original language description

Introduction: Acute tubulointerstitial nephritis (ATIN) is a well-recognized cause of acute kidney injury (AKI) due to the tubulointerstitial inflammation. The aim of this study was to explore the clinical features, outcomes, and responses to corticosteroid treatment in patients with ATIN. Methods: Patients with biopsy proven ATIN, who were diagnosed between 1994-2016 at the Department of Nephrology, Charles University, First Faculty of Medicine and General University Hospital in Prague, were included in the study. Patient demographics, the aetiological and clinical features, the treatment given, and the outcome at one year of follow up were extracted from patient records. Results: A total of 103 ATIN patients were analysed, of which 68 had been treated with corticosteroids. There was no significant difference in the median serum creatinine 280 (169-569) mu mol/l in the conservatively managed group vs. 374 (249-558) mu mol/l in the corticosteroid treated group, p = 0.18 and dependence on dialysis treatment at baseline at the time of biopsy (10.3% vs 8.6%). During the one year follow up, those ATIN patients who had been treated with corticosteroids did better and showed greater improvement in kidney function, determined as serum creatinine difference from baseline and from one month over one year period (p=0.001). Conclusions: This single center retrospective cohort study supports the beneficial role of the administration of corticosteroid therapy in the management of ATIN.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30217 - Urology and nephrology

Project

<a href="/en/project/LX22NPO5104" target="_blank" >LX22NPO5104: National Institute for Research of Metabolic and Cardiovascular Diseases</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Kidney &amp; Blood Pressure Research

ISSN

1420-4096

e-ISSN

1423-0143

Volume of the periodical

49

Issue of the periodical within the volume

1

Country of publishing house

CH - SWITZERLAND

Number of pages

8

Pages from-to

1-8

UT code for WoS article

001111194800001

EID of the result in the Scopus database

2-s2.0-85184296852