Carcinoma cellular uptake, imaging, and targeting by RGD- and TAT-conjugated upconversion and/or magnetic nanoparticles
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F17%3A00076327" target="_blank" >RIV/00023001:_____/17:00076327 - isvavai.cz</a>
Alternative codes found
RIV/61389013:_____/17:00474727
Result on the web
<a href="https://briefs.techconnect.org/books/biotech-biomaterials-and-biomedical-techconnect-briefs-2017/" target="_blank" >https://briefs.techconnect.org/books/biotech-biomaterials-and-biomedical-techconnect-briefs-2017/</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Carcinoma cellular uptake, imaging, and targeting by RGD- and TAT-conjugated upconversion and/or magnetic nanoparticles
Original language description
We have developed monodisperse magnetic Fe3O4, upconversion NaYF4:Yb3+/Er3+, and dual paramagnetic/upconversion NaGdF4:Yb3+/Er3+ nanoparticles with tunable size by thermal decomposition of Fe(III) oleate and lanthanide chlorides in hight-boiling organic solvents. Aminosilica and 4-pentynoic acid were then introduced on the particle surface to conjugate the cell adhesive and cell penetrating RGD and TAT peptides, respectively. Optionally, NaYF4:Yb3+/Er3+ @SiO2-NH2 particles reacted with methoxyPEG succinimidyl ester to diminish uptake of the particles by the reticulo-endothelial system. Neural stem cell viability and labeling efficiency of the particles were determined. Al carboxyphthalocyanine was conjugated to NaYF4:Yb3+/Er3+@SiO2-PEG nanoparticles, which were intravenously administered in athymic nude mice with xenotransplanated human prostate carcinoma PC-3. After NIR photodynamic therapy, the tumor subsided and its volume approached to zero.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
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OECD FORD branch
30224 - Radiology, nuclear medicine and medical imaging
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
TechConnect Briefs 2017 : Biotech, Biomaterials and Biomedical
ISBN
978-0-9988782-0-1
ISSN
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e-ISSN
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Number of pages
4
Pages from-to
114-117
Publisher name
TechConnect
Place of publication
Danville
Event location
Washington, US
Event date
May 14, 2017
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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