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Carcinoma cellular uptake, imaging, and targeting by RGD- and TAT-conjugated upconversion and/or magnetic nanoparticles

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F17%3A00474727" target="_blank" >RIV/61389013:_____/17:00474727 - isvavai.cz</a>

  • Alternative codes found

    RIV/00023001:_____/17:00076327

  • Result on the web

    <a href="https://briefs.techconnect.org/papers/carcinoma-cellular-uptake-imaging-and-targeting-by-rgds-and-tat-conjugated-upconversion-and-or-magnetic-nanoparticles/" target="_blank" >https://briefs.techconnect.org/papers/carcinoma-cellular-uptake-imaging-and-targeting-by-rgds-and-tat-conjugated-upconversion-and-or-magnetic-nanoparticles/</a>

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Carcinoma cellular uptake, imaging, and targeting by RGD- and TAT-conjugated upconversion and/or magnetic nanoparticles

  • Original language description

    We have developed monodisperse magnetic Fe3O4, upconversion NaYF4:Yb3+/Er3+, and dual paramagnetic/upconversion NaGdF4: Yb3+/Er3+ nanoparticles with tunable size by thermal decomposition of Fe(III) oleate and lanthanide chlorides in high-boiling organic solvents. Aminosilica and 4-pentynoic acid were then introduced on the particle surface to conjugate the cell adhesive and cell penetrating RGD and TAT peptides, respectively. Optionally, NaYF4:Yb3+/Er3+@SiO2-NH2 particles reacted with methoxyPEG succinimidyl ester to diminish uptake of the particles by the reticulo-endothelial system. Neural stem cell viability and labeling efficiency of the particles were determined. Al carboxyphthalocyanine was conjugated to NaYF4:Yb37Er3+@SiO2-PEG nanoparticles, which were intravenously administered in athymic nude mice with xenotransplanted human prostate carcinoma PC-3. After NIR photodynamic therapy, the tumor subsided and its volume approached to zero.

  • Czech name

  • Czech description

Classification

  • Type

    D - Article in proceedings

  • CEP classification

  • OECD FORD branch

    10404 - Polymer science

Result continuities

  • Project

    <a href="/en/project/GA15-01897S" target="_blank" >GA15-01897S: Magnetic or 90Y-radiolabeled light-upconverting nanoparticles for photodynamic therapy or radiotherapy of tumors</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    TechConnect Briefs 2017

  • ISBN

    978-0-9988782-0-1

  • ISSN

  • e-ISSN

  • Number of pages

    4

  • Pages from-to

    114-117

  • Publisher name

    TechConnect

  • Place of publication

    Danville

  • Event location

    Washington

  • Event date

    May 14, 2017

  • Type of event by nationality

    WRD - Celosvětová akce

  • UT code for WoS article