In vivo evaluation of short-term performance of new three-layer collagen-based vascular graft designed for low-flow peripheral vascular reconstructions
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F18%3A00076557" target="_blank" >RIV/00023001:_____/18:00076557 - isvavai.cz</a>
Result on the web
<a href="https://www.hindawi.com/journals/bmri/2018/3519596/" target="_blank" >https://www.hindawi.com/journals/bmri/2018/3519596/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2018/3519596" target="_blank" >10.1155/2018/3519596</a>
Alternative languages
Result language
angličtina
Original language name
In vivo evaluation of short-term performance of new three-layer collagen-based vascular graft designed for low-flow peripheral vascular reconstructions
Original language description
Aim. The aim of this study was to evaluate short-term patency of the new prosthetic graft and its structural changes after explantation. Methods. The study team developed a three-layer conduit composed of a scaffold made from polyester coated with collagen from the inner and outer side with an internal diameter of 6 mm. The conduit was implanted as a bilateral bypass to the carotid artery in 7 sheep and stenosis was created in selected animals. After a period of 161 days, the explants were evaluated as gross and microscopic specimens. Results. The initial flow rate (median +/- IQR) in grafts with and without artificial stenosis was 120 +/- 79 ml/min and 255 +/- 255 ml/min, respectively. Graft occlusion occurred after 99 days in one of 13 conduits (patency rate: 92%). Wall-adherent thrombi occurred only in sharp curvatures in two grafts. Microscopic evaluation showed good engraftment and preserved structure in seven conduits; inflammatory changes with foci of bleeding, necrosis, and disintegration in four conduits; and narrowing of the graft due to thickening of the wall with multifocal separation of the outer layer in two conduits. Conclusions. This study demonstrates good short-term patency rates of a newly designed three-layer vascular graft even in low-flow conditions in a sheep model.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30404 - Biomaterials (as related to medical implants, devices, sensors)
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BioMed research international [online]
ISSN
2314-6141
e-ISSN
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Volume of the periodical
2018
Issue of the periodical within the volume
February 27
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
"art. no. 3519596"
UT code for WoS article
000426122600001
EID of the result in the Scopus database
2-s2.0-85044026363