All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Early progression of cardiac allograft vasculopathy assessed by quantitative coronary angiography: A single centre prospective study

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F18%3A00076559" target="_blank" >RIV/00023001:_____/18:00076559 - isvavai.cz</a>

  • Result on the web

    <a href="https://ac.els-cdn.com/S0010865017300073/1-s2.0-S0010865017300073-main.pdf?_tid=df6e0182-c525-47cf-8af5-c85aadeca08b&acdnat=1523961862_4f28e9bb00f925c2028d6fe9314b62be" target="_blank" >https://ac.els-cdn.com/S0010865017300073/1-s2.0-S0010865017300073-main.pdf?_tid=df6e0182-c525-47cf-8af5-c85aadeca08b&acdnat=1523961862_4f28e9bb00f925c2028d6fe9314b62be</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.crvasa.2017.03.002" target="_blank" >10.1016/j.crvasa.2017.03.002</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Early progression of cardiac allograft vasculopathy assessed by quantitative coronary angiography: A single centre prospective study

  • Original language description

    Introduction: Early diagnosis of cardiac allograft vasculopathy (CAV) becomes a crucial step in management of post-transplant patients since it can be attenuated by specific clinical approaches. Materials and methods: We enrolled 48 consecutive patients in this prospective, observational, single centre study. Early development of CAV was assessed by two independent reviewers using quantitative coronary angiography (QCA) in the 1st and 12th month after heart transplantation (HTx). We examined the relationship between CAV and selected clinical and serological variables. Results: A significant mean lumen diameter (MLD) loss was observed in all major coronary artery branches within 12 months after HTx. MLD loss was as follows - RCA (3.52 mm -&gt; 3.25 mm, P = 0.0008), LCx (3.68 mm -&gt; 3.42 mm, P &lt; 0.0001) and LAD (3.95 mm -&gt; 3.69, P &lt; 0.0001). Among the patient cohort, 14 CAV rapid progressors (14/48, 29.2%) were identified. Their sum of MLD loss in all monitored arteries within 12 months after HTx reached &gt;= 10%. An increased heart rate in the 12th month after HTx reflected the younger age of a donor (P = 0.01), but was not associated with rapid progression of CAV. The most important predictor of rapid progression of CAV was increased serum level of B-type natriuretic peptide (BNP) soon after HTx (3rd day after HTx, P = 0.04). Conclusion: A significant reduction of MLD was observed in all major coronary arteries as early as within the first year after HTx. Early elevation of BNP serum levels predicted rapid progression of CAV. The presumption that faster heart rate is involved in the development of CAV in HTx recipients was not confirmed.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30201 - Cardiac and Cardiovascular systems

Result continuities

  • Project

  • Continuities

    N - Vyzkumna aktivita podporovana z neverejnych zdroju

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Cor et vasa

  • ISSN

    0010-8650

  • e-ISSN

  • Volume of the periodical

    60

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    7

  • Pages from-to

    "E59"-"E65"

  • UT code for WoS article

    000426976600011

  • EID of the result in the Scopus database

    2-s2.0-85017117435