Early progression of cardiac allograft vasculopathy assessed by quantitative coronary angiography: A single centre prospective study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F18%3A00076559" target="_blank" >RIV/00023001:_____/18:00076559 - isvavai.cz</a>
Result on the web
<a href="https://ac.els-cdn.com/S0010865017300073/1-s2.0-S0010865017300073-main.pdf?_tid=df6e0182-c525-47cf-8af5-c85aadeca08b&acdnat=1523961862_4f28e9bb00f925c2028d6fe9314b62be" target="_blank" >https://ac.els-cdn.com/S0010865017300073/1-s2.0-S0010865017300073-main.pdf?_tid=df6e0182-c525-47cf-8af5-c85aadeca08b&acdnat=1523961862_4f28e9bb00f925c2028d6fe9314b62be</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.crvasa.2017.03.002" target="_blank" >10.1016/j.crvasa.2017.03.002</a>
Alternative languages
Result language
angličtina
Original language name
Early progression of cardiac allograft vasculopathy assessed by quantitative coronary angiography: A single centre prospective study
Original language description
Introduction: Early diagnosis of cardiac allograft vasculopathy (CAV) becomes a crucial step in management of post-transplant patients since it can be attenuated by specific clinical approaches. Materials and methods: We enrolled 48 consecutive patients in this prospective, observational, single centre study. Early development of CAV was assessed by two independent reviewers using quantitative coronary angiography (QCA) in the 1st and 12th month after heart transplantation (HTx). We examined the relationship between CAV and selected clinical and serological variables. Results: A significant mean lumen diameter (MLD) loss was observed in all major coronary artery branches within 12 months after HTx. MLD loss was as follows - RCA (3.52 mm -> 3.25 mm, P = 0.0008), LCx (3.68 mm -> 3.42 mm, P < 0.0001) and LAD (3.95 mm -> 3.69, P < 0.0001). Among the patient cohort, 14 CAV rapid progressors (14/48, 29.2%) were identified. Their sum of MLD loss in all monitored arteries within 12 months after HTx reached >= 10%. An increased heart rate in the 12th month after HTx reflected the younger age of a donor (P = 0.01), but was not associated with rapid progression of CAV. The most important predictor of rapid progression of CAV was increased serum level of B-type natriuretic peptide (BNP) soon after HTx (3rd day after HTx, P = 0.04). Conclusion: A significant reduction of MLD was observed in all major coronary arteries as early as within the first year after HTx. Early elevation of BNP serum levels predicted rapid progression of CAV. The presumption that faster heart rate is involved in the development of CAV in HTx recipients was not confirmed.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cor et vasa
ISSN
0010-8650
e-ISSN
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Volume of the periodical
60
Issue of the periodical within the volume
1
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
"E59"-"E65"
UT code for WoS article
000426976600011
EID of the result in the Scopus database
2-s2.0-85017117435