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Donor specific anti-HLA antibodies and cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00080788" target="_blank" >RIV/00023001:_____/21:00080788 - isvavai.cz</a>

  • Alternative codes found

    RIV/00209775:_____/21:N0000019 RIV/00159816:_____/21:00074723 RIV/00064190:_____/21:N0000072 RIV/00216208:11110/21:10416587 and 3 more

  • Result on the web

    <a href="https://reader.elsevier.com/reader/sd/pii/S0966327420301489?token=0137EA8BF6D421ACF9D70C22041C0846744314FFEDB5A4CF345B8707B112DF6E4B9ABE00DF22A5D41868B87B2F0F2E9F" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S0966327420301489?token=0137EA8BF6D421ACF9D70C22041C0846744314FFEDB5A4CF345B8707B112DF6E4B9ABE00DF22A5D41868B87B2F0F2E9F</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.trim.2020.101340" target="_blank" >10.1016/j.trim.2020.101340</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Donor specific anti-HLA antibodies and cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis

  • Original language description

    Introduction: Recent studies suggested potential positive correlations between HLA-specific antibodies and development of cardiac allograft vasculopathy (CAV). Methods: This prospective two-center study investigated early progression of CAV by coronary optical coherence tomography in 1 month and 12 months after heart transplantation (HTx) in 104 patients. Detection and characterization of donor specific (DSA) and MHC class-I polypeptide-related sequence A (MICA) antibodies were performed before, 1, 6 and 12 months after transplantation. Results: During the first post-HTx year, we observed a significant reduction in the mean coronary luminal area (P &lt;.001), and progression in mean intimal thickness (IT) (P &lt;.001). DSA and anti-MICA occurred in 17% of all patients, but no significant relationship was observed between presence of DSA/anti-MICA and IT progression within 12 months after HTx. In contrast, we observed significant association between presence of DSA (p=0.031), de-novo DSA (p=0.031), HLA Class II DSA (p=0.017) and media thickness (MT) progression. Conclusion: Results of our study did not identify a direct association between presence of DSA/anti-MICA and intimal thickness progression in an early period after HTx. However, we found significant relationships between DSA and media thickness progression that may identify a newly recognized immune-pathological aspect of CAV. © 2020 Elsevier B.V.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30213 - Transplantation

Result continuities

  • Project

    <a href="/en/project/NV16-27465A" target="_blank" >NV16-27465A: Assessment of cardiac allograft vasculopathy by optical coherence tomography</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Transplant immunology

  • ISSN

    0966-3274

  • e-ISSN

  • Volume of the periodical

    65

  • Issue of the periodical within the volume

    April

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    8

  • Pages from-to

    "art. no. 101340"

  • UT code for WoS article

    000633033800006

  • EID of the result in the Scopus database

    2-s2.0-85094857312