Donor specific anti-HLA antibodies and cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00080788" target="_blank" >RIV/00023001:_____/21:00080788 - isvavai.cz</a>
Alternative codes found
RIV/00209775:_____/21:N0000019 RIV/00159816:_____/21:00074723 RIV/00064190:_____/21:N0000072 RIV/00216208:11110/21:10416587 and 3 more
Result on the web
<a href="https://reader.elsevier.com/reader/sd/pii/S0966327420301489?token=0137EA8BF6D421ACF9D70C22041C0846744314FFEDB5A4CF345B8707B112DF6E4B9ABE00DF22A5D41868B87B2F0F2E9F" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S0966327420301489?token=0137EA8BF6D421ACF9D70C22041C0846744314FFEDB5A4CF345B8707B112DF6E4B9ABE00DF22A5D41868B87B2F0F2E9F</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.trim.2020.101340" target="_blank" >10.1016/j.trim.2020.101340</a>
Alternative languages
Result language
angličtina
Original language name
Donor specific anti-HLA antibodies and cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis
Original language description
Introduction: Recent studies suggested potential positive correlations between HLA-specific antibodies and development of cardiac allograft vasculopathy (CAV). Methods: This prospective two-center study investigated early progression of CAV by coronary optical coherence tomography in 1 month and 12 months after heart transplantation (HTx) in 104 patients. Detection and characterization of donor specific (DSA) and MHC class-I polypeptide-related sequence A (MICA) antibodies were performed before, 1, 6 and 12 months after transplantation. Results: During the first post-HTx year, we observed a significant reduction in the mean coronary luminal area (P <.001), and progression in mean intimal thickness (IT) (P <.001). DSA and anti-MICA occurred in 17% of all patients, but no significant relationship was observed between presence of DSA/anti-MICA and IT progression within 12 months after HTx. In contrast, we observed significant association between presence of DSA (p=0.031), de-novo DSA (p=0.031), HLA Class II DSA (p=0.017) and media thickness (MT) progression. Conclusion: Results of our study did not identify a direct association between presence of DSA/anti-MICA and intimal thickness progression in an early period after HTx. However, we found significant relationships between DSA and media thickness progression that may identify a newly recognized immune-pathological aspect of CAV. © 2020 Elsevier B.V.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30213 - Transplantation
Result continuities
Project
<a href="/en/project/NV16-27465A" target="_blank" >NV16-27465A: Assessment of cardiac allograft vasculopathy by optical coherence tomography</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Transplant immunology
ISSN
0966-3274
e-ISSN
—
Volume of the periodical
65
Issue of the periodical within the volume
April
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
"art. no. 101340"
UT code for WoS article
000633033800006
EID of the result in the Scopus database
2-s2.0-85094857312