Circulating tumor cells mirror bone metastatic phenotype in prostate cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F18%3A00077374" target="_blank" >RIV/00023001:_____/18:00077374 - isvavai.cz</a>
Result on the web
<a href="http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path" target="_blank" >http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.18632/oncotarget.25634" target="_blank" >10.18632/oncotarget.25634</a>
Alternative languages
Result language
angličtina
Original language name
Circulating tumor cells mirror bone metastatic phenotype in prostate cancer
Original language description
Circulating tumor cells (CTCs) are promising biomarkers in prostate cancer (PC) because they derive from primary tumor and metastatic tissues. In this study, we used quantitative real-time PCR (qPCR) to compare the expression profiles of 41 PC-related genes between paired CTC and spinal column metastasis samples from 22 PC patients that underwent surgery for spinal cord compression. We observed good concordance between the gene expression profiles in the CTC and metastasis samples in most of the PC patients. Expression of nine genes (AGR2, AKR1C3, AR, CDH1, FOLH1, HER2, KRT19, MDK, and SPINK1) showed a significant correlation between the CTC and metastasis samples. Hierarchical clustering analysis showed a similar grouping of PC patients based on the expression of these nine genes in both CTC and metastasis samples. Our findings demonstrate that CTCs mirror gene expression patterns in tissue metastasis samples from PC patients. Although low detection frequency of certain genes is a limitation in CTCs, our results indicate the potential for CTC phenotyping as a tool to improve individualized therapy in metastatic prostate cancer.
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Oncotarget [online]
ISSN
1949-2553
e-ISSN
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Volume of the periodical
9
Issue of the periodical within the volume
50
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
29403-29413
UT code for WoS article
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EID of the result in the Scopus database
2-s2.0-85049195585