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Circulating tumor cells mirror bone metastatic phenotype in prostate cancer

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F18%3A00077374" target="_blank" >RIV/00023001:_____/18:00077374 - isvavai.cz</a>

  • Result on the web

    <a href="http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path" target="_blank" >http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.18632/oncotarget.25634" target="_blank" >10.18632/oncotarget.25634</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Circulating tumor cells mirror bone metastatic phenotype in prostate cancer

  • Original language description

    Circulating tumor cells (CTCs) are promising biomarkers in prostate cancer (PC) because they derive from primary tumor and metastatic tissues. In this study, we used quantitative real-time PCR (qPCR) to compare the expression profiles of 41 PC-related genes between paired CTC and spinal column metastasis samples from 22 PC patients that underwent surgery for spinal cord compression. We observed good concordance between the gene expression profiles in the CTC and metastasis samples in most of the PC patients. Expression of nine genes (AGR2, AKR1C3, AR, CDH1, FOLH1, HER2, KRT19, MDK, and SPINK1) showed a significant correlation between the CTC and metastasis samples. Hierarchical clustering analysis showed a similar grouping of PC patients based on the expression of these nine genes in both CTC and metastasis samples. Our findings demonstrate that CTCs mirror gene expression patterns in tissue metastasis samples from PC patients. Although low detection frequency of certain genes is a limitation in CTCs, our results indicate the potential for CTC phenotyping as a tool to improve individualized therapy in metastatic prostate cancer.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database

  • CEP classification

  • OECD FORD branch

    30204 - Oncology

Result continuities

  • Project

  • Continuities

    N - Vyzkumna aktivita podporovana z neverejnych zdroju

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Oncotarget [online]

  • ISSN

    1949-2553

  • e-ISSN

  • Volume of the periodical

    9

  • Issue of the periodical within the volume

    50

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    11

  • Pages from-to

    29403-29413

  • UT code for WoS article

  • EID of the result in the Scopus database

    2-s2.0-85049195585