Gene expression profiling of circulating tumor cells and peripheral blood mononuclear cells from breast cancer patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F16%3A00459302" target="_blank" >RIV/86652036:_____/16:00459302 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/16:10323448 RIV/00216208:11130/16:10323448 RIV/00064203:_____/16:10323448

Result on the web

<a href="http://dx.doi.org/10.1080/2162402X.2015.1102827" target="_blank" >http://dx.doi.org/10.1080/2162402X.2015.1102827</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/2162402X.2015.1102827" target="_blank" >10.1080/2162402X.2015.1102827</a>

Result language

angličtina

Original language name

Gene expression profiling of circulating tumor cells and peripheral blood mononuclear cells from breast cancer patients

Original language description

Circulating tumor cells (CTCs) are cancer cells that are released from a tumor into the bloodstream. The presence of CTCs in peripheral blood has been associated with metastasis formation in patients with breast cancer. Therefore, the molecular characterization of CTCs may improve diagnostics and support treatment decisions.We performed gene expression profiling to evaluate the enriched CTCs and peripheral blood mononuclear cells (PBMCs) of breast cancer patients using an expression panel of 55 breast cancer-associated genes. The study revealed several significantly differentially expressed genes in the CTC-positive samples, including a few that were exclusively expressed in these cells. However, the expression of these genes was barely detectable in the PBMC samples. Some genes were differentially expressed in PBMCs, and the expression of these genes was correlated with tumor grade and the formation of metastasis.In this study, we have shown that the enriched CTCs of breast cancer patients overexpress genes involved in proteolytic degradation of the extracellular matrix (ECM) as well as genes that play important roles in the epithelial-mesenchymal transition (EMT) process that may occur in these cells.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/NT11404" target="_blank" >NT11404: Hematogeneous micrometastases from breast cancer and its significance for clinical outcome and possibilities of next treatment.</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ONCOIMMUNOLOGY

ISSN

2162-402X

e-ISSN

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Volume of the periodical

5

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

12

Pages from-to

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UT code for WoS article

000374194200017

EID of the result in the Scopus database

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