Detection of circulating tumor cells during follow-up of patients with early breast cancer: Clinical utility for monitoring of therapy efficacy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10193696" target="_blank" >RIV/00216208:11110/14:10193696 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22340/14:43897828 RIV/00064165:_____/14:10193696
Result on the web
<a href="http://informahealthcare.com/eprint/bJUDhySSw3pF9WIsQQ85/full" target="_blank" >http://informahealthcare.com/eprint/bJUDhySSw3pF9WIsQQ85/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/00365513.2013.864784" target="_blank" >10.3109/00365513.2013.864784</a>

Result language
angličtina
Original language name
Detection of circulating tumor cells during follow-up of patients with early breast cancer: Clinical utility for monitoring of therapy efficacy
Original language description
Introduction. Circulating tumor cells (CTCs) detection prior to and during therapy is considered as an independent and strong prognostic marker. The present study was designed to isolate and characterize CTCs in peripheral blood of an early breast cancer(BC) patient as a biomarker for monitoring treatments efficacy. Materials and methods. In total, 54 early breast cancer patients undergoing neoadjuvant and/or adjuvant chemotherapy regimens were enrolled into a prospective study. CTC detection in bloodwas performed by AdnaTest BreastCancer (TM) (AdnaGen AG, Germany), which is based on the detection of EpCAM, HER2 and MUC1 specific transcripts in enriched CTC-lysates. Additionally, cDNA from isolated CTCs and PBMC was used for qPCR gene expression analysis of TOP1, TOP2A, CTSD, ST6, CK19 and reference gene actin. Results. We found that CTCs can be detected in the peripheral blood of approximately 31% of early stage breast cancer patients. The presence of CTCs was detected in 36% ER pos
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical
Scandinavian Journal of Clinical and Laboratory Investigation
ISSN
0036-5513
e-ISSN
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Volume of the periodical
74
Issue of the periodical within the volume
2
Country of publishing house
NO - NORWAY
Number of pages
11
Pages from-to
132-142
UT code for WoS article
000334737700008
EID of the result in the Scopus database
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