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Circulating Tumor Cells in Patients with Breast Cancer: Monitoring Chemotherapy Success

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10287019" target="_blank" >RIV/00216208:11110/14:10287019 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11120/14:43908598 RIV/00064173:_____/14:#0000404 RIV/00064165:_____/14:10287019

  • Result on the web

    <a href="http://iv.iiarjournals.org/content/28/4/605.short" target="_blank" >http://iv.iiarjournals.org/content/28/4/605.short</a>

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Circulating Tumor Cells in Patients with Breast Cancer: Monitoring Chemotherapy Success

  • Original language description

    Circulating tumor cells (CTCs) are an independent prognostic factor for patients with metastatic breast cancer (MBC). However, the role of CTCs in early breast cancer management is not yet clearly defined. The aim of this study was to assess the CTC-positivity rate in patients undergoing chemotherapy depending on breast cancer stage in the adjuvant and neoadjuvant setting. We evaluated the ability to confirm therapy response by CTC analysis. CTCs isolated from blood by means of immunomagnetic separationwere further characterized by means of reverse transcriptase polymerase chain reaction (RT-PCR) for epithelial cell adhesion molecule (EPCAM), mucin 1 (MUC1) and v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (HER2) transcripts with theAdnaTest (TM). This prospective study included 179 patients; altogether 419 blood samples were evaluated. Patients with primary tumors were divided into neoadjuvant (n=38), and adjuvant (n=100) groups. Forty-one patients with MBC were ev

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/NT14441" target="_blank" >NT14441: Circulating and disseminated tumor cells in diagnosis and treatment of advanced ovarian cancer.</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2014

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    In Vivo

  • ISSN

    0258-851X

  • e-ISSN

  • Volume of the periodical

    28

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    GR - GREECE

  • Number of pages

    10

  • Pages from-to

    605-614

  • UT code for WoS article

    000338777500026

  • EID of the result in the Scopus database