Self-assembled thermoresponsive polymeric nanogels for F-19 MR imaging

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F18%3A00077430" target="_blank" >RIV/00023001:_____/18:00077430 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/18:10377893 RIV/46747885:24220/18:00005499 RIV/00216208:11110/18:10377893
Result on the web
<a href="https://pubs.acs.org/doi/abs/10.1021/acs.biomac.8b00812" target="_blank" >https://pubs.acs.org/doi/abs/10.1021/acs.biomac.8b00812</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.biomac.8b00812" target="_blank" >10.1021/acs.biomac.8b00812</a>

Result language
angličtina
Original language name
Self-assembled thermoresponsive polymeric nanogels for F-19 MR imaging
Original language description
Magnetic resonance imaging using fluorinated contrast agents (F-19 MRI) enables to achive highcontrast in images due to the negligible fluorine background in living tissues. In this pilot study, we developed new biocompatible, temperature-responsive, and easily synthesized polymeric nanogels containing a sufficient concentration of magnetically equivalent fluorine atoms for F-19 MRI purposes. The structure of the nanogels is based on amphiphilic copolymers containing two blocks, a hydrophilic poly-[N-(2-hydroxypropyl)-methacrylamide] (PHPMA) or poly(2-methyl-2-oxazoline) (PMeOx) block, and a thermoresponsive poly[N(2,2difluoroethyl)acrylamide] (PDFEA) block. The thermoresponsive properties of the PDFEA block allow us to control the process of nanogel self-assembly upon its heating in an aqueous solution. Particle size depends on the copolymer composition, and the most promising copolymers with longer thermoresponsive blocks form nanogels of suitable size for angiogenesis imaging or the labeling of cells (approximately 120 nm). The in vitro F-19 MRI experiments reveal good sensitivity of the copolymer contrast agents, while the nanogels were proven to be noncytotoxic for several cell lines.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology

Project
<a href="/en/project/GA16-03156S" target="_blank" >GA16-03156S: Self-assembled polymeric nanostructures as bimodal magnetic resonance ultrasound contrast agents for imaging</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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