Thermoresponsive triblock copolymers as widely applicable 19F magnetic resonance imaging tracers

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F22%3A00565996" target="_blank" >RIV/61389013:_____/22:00565996 - isvavai.cz</a>

Alternative codes found

RIV/61388963:_____/22:00567188 RIV/00216208:11110/22:10452769 RIV/00216208:11310/22:10452769

Result on the web

<a href="https://pubs.acs.org/doi/10.1021/acs.chemmater.2c02589" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.chemmater.2c02589</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.chemmater.2c02589" target="_blank" >10.1021/acs.chemmater.2c02589</a>

Result language

angličtina

Original language name

Thermoresponsive triblock copolymers as widely applicable 19F magnetic resonance imaging tracers

Original language description

Fluorine-19 magnetic resonance imaging (19F MRI) has emerged as a promising noninvasive diagnostic tool, broadening the diagnostic possibilities of commonly used proton MRI. Despite the potential of 19F MRI, an ideal tracer paving the way toward the entry of this method into common medical practice is yet to be developed. In this study, we report on a series of polymeric systems based on thermoresponsive poly[N-(2,2-difluoroethyl)acrylamide] (PDFEA), a polymer considered to be an ideal tracer for 19F MRI. The described systems are designed as BAB triblock copolymers, where B corresponds to thermoresponsive PDFEA blocks and A is a hydrophilic poly(ethylene glycol) block. These BAB triblock copolymers are able to form nanoparticles in dilute aqueous solutions, which undergo a transition into physically cross-linked hydrogels upon increasing the polymer concentration. Since thermoresponsive particle- and hydrogel-based systems are applicable in a wide range of biomedical applications, we created a diagnostic system with potential therapeutic properties (theranostic) as a widely tunable platform through straightforward synthesis while serving a multitude of applications. We analyzed the effect of the BAB block ratio on the self-assembly, thermoresponsiveness, and mechanical properties of the studied hydrogels, together with their suitability for 19F MRI. Finally, their biocompatibility was assessed on a relevant cell line.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10404 - Polymer science

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chemistry of Materials

ISSN

0897-4756

e-ISSN

1520-5002

Volume of the periodical

34

Issue of the periodical within the volume

24

Country of publishing house

US - UNITED STATES

Number of pages

15

Pages from-to

10902-10916

UT code for WoS article

000906402700001

EID of the result in the Scopus database

2-s2.0-85143978635