Fluorinated ferrocene moieties as a platform for redox-responsive polymer 19F MRI theranostics
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F22%3A00552887" target="_blank" >RIV/61388955:_____/22:00552887 - isvavai.cz</a>
Alternative codes found
RIV/61389013:_____/22:00552887 RIV/61388963:_____/22:00552363 RIV/00216208:11110/22:10443814 RIV/00216208:11320/22:10443814 RIV/00216208:11310/22:10443814
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acs.macromol.1c01723" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.macromol.1c01723</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.macromol.1c01723" target="_blank" >10.1021/acs.macromol.1c01723</a>
Alternative languages
Result language
angličtina
Original language name
Fluorinated ferrocene moieties as a platform for redox-responsive polymer 19F MRI theranostics
Original language description
Fluorine-19 magnetic resonance imaging (19F MRI) stands out as a powerful tool for noninvasive diagnostics. In particular, polymer-based 19F MRI tracers offer tunable physicochemical properties, including solubility and thermoresponsiveness, and enhanced 19F MRI performance. However, these tracers do not detectably respond to redox changes or do so in only one redox state, thereby preventing potential applications to reactive oxygen species (ROS) bioimaging. Herein, we report the first amphiphilic redox-responsive, poly(2-oxazoline)-based polymers bearing fluorinated ferrocene moieties. Their hydrophobicity and redox responsiveness were tailored by changing the monomer ratio and substitution pattern of the fluorinated ferrocene units. Converting the diamagnetic fluorinated ferrocene moieties into paramagnetic ferrocenium markedly changed the chemical shift and relaxation times of the 19F nuclei distinguishable by 19F MRI. In turn, the statistical–diblock copolymers formed nanoparticles that disassemble upon oxidation, with no toxicity to cultured cells. Therefore, these polymers may be used to release lipophilic drugs in ROS-rich malignancies.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Macromolecules
ISSN
0024-9297
e-ISSN
1520-5835
Volume of the periodical
55
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
658-671
UT code for WoS article
000739491900001
EID of the result in the Scopus database
2-s2.0-85122812925