Synthesis of 19F MRI nanotracers by dispersion polymerization-induced self-assembly of N-(2,2,2-trifluoroethyl)acrylamide in water

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F22%3A00563955" target="_blank" >RIV/61389013:_____/22:00563955 - isvavai.cz</a>
Alternative codes found
RIV/00023001:_____/22:00083744 RIV/00216208:11310/22:10452660 RIV/46747885:24530/22:00010471
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acs.biomac.2c00981" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.biomac.2c00981</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.biomac.2c00981" target="_blank" >10.1021/acs.biomac.2c00981</a>

Result language
angličtina
Original language name
Synthesis of 19F MRI nanotracers by dispersion polymerization-induced self-assembly of N-(2,2,2-trifluoroethyl)acrylamide in water
Original language description
19F magnetic resonance imaging (MRI) using fluoropolymer tracers has recently emerged as a promising, non-invasive diagnostic tool in modern medicine. However, despite its potential, 19F MRI remains overlooked and underused due to the limited availability or unfavorable properties of fluorinated tracers. Herein, we report a straightforward synthetic route to highly fluorinated 19F MRI nanotracers via aqueous dispersion polymerization-induced self-assembly of a water-soluble fluorinated monomer. A polyethylene glycol-based macromolecular chain-transfer agent was extended by RAFT-mediated N-(2,2,2-trifluoroethyl)acrylamide (TFEAM) polymerization in water, providing fluorine-rich self-assembled nanoparticles in a single step. The resulting nanoparticles had different morphologies and sizes ranging from 60 to 220 nm. After optimizing their structure to maximize the magnetic relaxation of the fluorinated core, we obtained a strong 19F NMR/MRI signal in an aqueous environment. Their non-toxicity was confirmed on primary human dermal fibroblasts. Moreover, we visualized the nanoparticles by 19F MRI, both in vitro (in aqueous phantoms) and in vivo (after subcutaneous injection in mice), thus confirming their biomedical potential.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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