Antibody-mediated rejection after liver transplantation - relevance of C1q and C3d-binding antibodies
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F18%3A00077474" target="_blank" >RIV/00023001:_____/18:00077474 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/abs/10.1111/tan.13354" target="_blank" >https://onlinelibrary.wiley.com/doi/abs/10.1111/tan.13354</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/tan.13354" target="_blank" >10.1111/tan.13354</a>
Alternative languages
Result language
angličtina
Original language name
Antibody-mediated rejection after liver transplantation - relevance of C1q and C3d-binding antibodies
Original language description
The aim of our study was to evaluate the relevance of complement-binding donor-specific antibodies (DSA) for prediction of antibody-mediated rejection (AMR) after liver transplantation. Sera from 123 liver transplant recipients were retrospectively defined for HLA specificity and complement-fixing activity using the single antigen beads, C1q and C3d techniques. Liver-recipients' sera were tested before transplantation, 3, 6 months and 1 year after transplantation. Patients were followed up for graft survival and rejection incidence for 1 year after transplantation. All patients with pretransplant complement-binding DSA developed severe AMR after transplantation, while three recipients out of four, who produced de novo complement-fixing DSA, developed AMR. Definition of DSA with respect to complement-fixing activity may provide clinically relevant information about the risk of AMR after liver transplantation.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30102 - Immunology
Result continuities
Project
<a href="/en/project/NV16-27477A" target="_blank" >NV16-27477A: Diagnostics of antibody-mediated rejection after liver transplantation</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
HLA
ISSN
2059-2302
e-ISSN
—
Volume of the periodical
92
Issue of the periodical within the volume
Supplement 2
Country of publishing house
US - UNITED STATES
Number of pages
4
Pages from-to
34-37
UT code for WoS article
000454095400002
EID of the result in the Scopus database
2-s2.0-85058387274