Independent effect of atrial fibrillation on natriuretic peptide release
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00077643" target="_blank" >RIV/00023001:_____/19:00077643 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/article/10.1007/s00392-018-1332-1" target="_blank" >https://link.springer.com/article/10.1007/s00392-018-1332-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00392-018-1332-1" target="_blank" >10.1007/s00392-018-1332-1</a>
Alternative languages
Result language
angličtina
Original language name
Independent effect of atrial fibrillation on natriuretic peptide release
Original language description
Background: We investigated whether the increase of plasma natriuretic peptides (NPs) in atrial fibrillation (AF) is independent of the effect of AF on the left atrial (LA) hemodynamics. Methods: Hemodynamically stable patients scheduled for AF ablation underwent assessment of B-type natriuretic peptide (BNP) and mid-regional pro-atrial natriuretic peptide (MR-proANP), echocardiography, and direct measurement of left atrial (LA) pressure. Concentrations of the NPs were compared between patients in AF (n=31) and controls in sinus rhythm (SR; n=31) who were matched for age, gender, heart rate, left ventricular ejection fraction, LA volume index, and directly measured mean LA pressure. Eighteen patients underwent serial measurement of NPs and LA pressure during native SR and after 20min of pacing-induced AF. Results: Compared to the patients in SR, the patients in AF had 2.6 times higher unadjusted BNP [median (inter-quartile range), 101 (63, 129) vs. 38 (26, 79) ng/L] and two times higher unadjusted MR-proANP [183 (140, 230) vs. 91 (67, 135) pmol/L; both p<0.001]. Concentrations of both NPs correlated with mean LA pressure in the patients in SR (r=0.75 for BNP and 0.62 for MR-proANP, both p<0.001) but not in the patients in AF (r=0.18 and 0.04, respectively, both p>0.3). Both NPs increased significantly during induced AF [adjusted median (IQR) relative change, BNP: 27 (22; 40)%, MR-proANP: 75 (64; 99)%, both p<0.001] without a significant change in the LA pressure.Conclusions: The increase of NPs in AF was independent of its effect on the LA hemodynamics.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical research in cardiology
ISSN
1861-0684
e-ISSN
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Volume of the periodical
108
Issue of the periodical within the volume
2
Country of publishing house
DE - GERMANY
Number of pages
8
Pages from-to
142-149
UT code for WoS article
000457491800003
EID of the result in the Scopus database
2-s2.0-85050826851