Fenofibrate decreases hepatic P-glycoprotein in a rat model of hereditary hypertriglyceridemia

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00077658" target="_blank" >RIV/00023001:_____/19:00077658 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/19:73594032
Result on the web
<a href="https://www.frontiersin.org/articles/10.3389/fphar.2019.00056/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fphar.2019.00056/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fphar.2019.00056" target="_blank" >10.3389/fphar.2019.00056</a>

Result language
angličtina
Original language name
Fenofibrate decreases hepatic P-glycoprotein in a rat model of hereditary hypertriglyceridemia
Original language description
P-glycoprotein (P-gp) is a membrane-bound transporter encoded by Mdr1a/Abcb1a and Mdr1b/Abcb1b genes in rodents involved in the efflux of cytotoxic chemicals and metabolites from cells. Modulation of its activity influences P-gp-mediated drug delivery and drug-drug interaction (DDI). In the current study, we tested the effects of fenofibrate on P-gp mRNA and protein content in non-obese model of metabolic syndrome. Males hereditary hypertriglyceridemic rats (HHTg) were fed standard laboratory diet (STD) (Controls) supplemented with micronized fenofibrate in lower (25 mg/kg b. wt./day) or in higher (100 mg/kg b. wt./day) dose for 4 weeks. Liver was used for the subsequent mRNA and protein content analysis. Fenofibrate in lower dose decreased hepatic Mdr1a by 75% and Mdr1b by 85%, while fenofibrate in higher dose decreased Mdr1a by 90% and Mdr1b by 92%. P-gp protein content in the liver was decreased by 74% in rat treated with fenofibrate at lower dose and by 88% in rats using fenofibrate at higher dose. These findings demonstrate for the first time that fenofibrate decreases both mRNA and protein amount of P-gp and suggest that fenofibrate could affect bioavailability and interaction of drugs used to treat dyslipidemia-induced metabolic disorders.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy

Project
<a href="/en/project/GA17-08888S" target="_blank" >GA17-08888S: Effect of silymarin combined with hypolipidemics on mechanisms leading to lipids accumulation, oxidative stress and inflammation in metabolic syndrome</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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