Lycopene increases metabolic activity of rat liver CYP2B, CYP2D and CYP3A
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F20%3A43878599" target="_blank" >RIV/62157124:16370/20:43878599 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/20:00115263 RIV/00209805:_____/20:00078391
Result on the web
<a href="https://link.springer.com/article/10.1007/s43440-019-00007-y" target="_blank" >https://link.springer.com/article/10.1007/s43440-019-00007-y</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s43440-019-00007-y" target="_blank" >10.1007/s43440-019-00007-y</a>
Alternative languages
Result language
angličtina
Original language name
Lycopene increases metabolic activity of rat liver CYP2B, CYP2D and CYP3A
Original language description
Background: Lycopene as a naturally occurring carotenoid is a common part of the human diet. Several beneficial properties of lycopene have been identified, with the most studied being anti-cancer and antioxidant activity. However, no evidence of possible drug-drug or drug-food supplement interactions has been found. Methods: We studied the in vivo effect of lycopene on the selected rat liver cytochromes P450 (CYPs): CYP1A2, CYP2B, CYP2C11, CYP2C6, CYP2D, and CYP3A. Lycopene was administered to rats intragastrically at doses of 4, 20, and 100 mg/kg/day for 10 consecutive days. Total protein content, P450 Content, and metabolic activity of selected CYPs were evaluated in the rat liver microsomal fraction. Results: Increased CYP2B, CYP2D, and CYP3A metabolic activities were observed in animals treated with the lycopene dose of 100 mg/kg/day. The content of CYP3A1 protein was increased by the dose of 100 mg/kg/day and CYP3A2 protein was increased by all administered doses of lycopene. Conclusion: The results of our study indicate that lycopene increased the metabolic activity of enzymes that are orthologues to the most clinically important human enzymes involved in xenobiotic metabolism. The risk of pharmacokinetic interactions between lycopene dietary supplements and co-administered drugs should be evaluated.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pharmacological Reports
ISSN
1734-1140
e-ISSN
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Volume of the periodical
72
Issue of the periodical within the volume
1
Country of publishing house
PL - POLAND
Number of pages
10
Pages from-to
156-165
UT code for WoS article
000522947600016
EID of the result in the Scopus database
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