Outcomes of liver transplantation for non-alcoholic steatohepatitis: A European liver transplant registry study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00078134" target="_blank" >RIV/00023001:_____/19:00078134 - isvavai.cz</a>

Result on the web

<a href="https://reader.elsevier.com/reader/sd/pii/S0168827819302727?token=232FF6F9A817EE80AEBC04A5604BDE9DC467E7876337FCB17F625DF5C1A339963827369461105DDD1DA1305AA178A04D" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S0168827819302727?token=232FF6F9A817EE80AEBC04A5604BDE9DC467E7876337FCB17F625DF5C1A339963827369461105DDD1DA1305AA178A04D</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jhep.2019.04.011" target="_blank" >10.1016/j.jhep.2019.04.011</a>

Result language

angličtina

Original language name

Outcomes of liver transplantation for non-alcoholic steatohepatitis: A European liver transplant registry study

Original language description

Background &amp; Aims: Little is known about outcomes of liver transplantation for patients with non-alcoholic steatohepatitis (NASH). We aimed to determine the frequency and outcomes of liver transplantation for patients with NASH in Europe and identify prognostic factors. Methods: We analysed data from patients transplanted for endstage liver disease between January 2002 and December 2016 using the European Liver Transplant Registry database. We compared data between patients with NASH versus other aetiologies. The principle endpoints were patient and overall allograft survival. Results: Among 68,950 adults undergoing first liver transplantation, 4.0% were transplanted for NASH - an increase from 1.2% in 2002 to 8.4% in 2016. A greater proportion of patients transplanted for NASH (39.1%) had hepatocellular carcinoma (HCC) than non-NASH patients (28.9%, p &lt;0.001). NASH was not significantly associated with survival of patients (hazard ratio [HR] 1.02, p = 0.713) or grafts (HR 0.99; p = 0.815) after accounting for available recipient and donor variables. Infection (24.0%) and cardio/cerebrovascular complications (5.3%) were the commonest causes of death in patients with NASH without HCC. Increasing recipient age (61-65 years: HR 2.07, p &lt;0.001; &gt;65: HR 1.72, p = 0.017), elevated model for end-stage liver disease score (&gt;23: HR 1.48, p = 0.048) and low (&lt;18.5 kg/m(2): HR 4.29, p = 0.048) or high (&gt;40 kg/m(2): HR 1.96, p = 0.012) recipient body mass index independently predicted death in patients transplanted for NASH without HCC. Data must be interpreted in the context of absent recognised confounders, such as premorbid metabolic risk factors. Conclusions: The number and proportion of liver transplants performed for NASH in Europe has increased from 2002 through 2016. HCC was more common in patients transplanted with NASH. Survival of patients and grafts in patients with NASH is comparable to that of other disease indications. Lay summary: The prevalence of non-alcoholic fatty liver disease has increased dramatically in parallel with the worldwide increase in obesity and diabetes. Its progressive form, non-alcoholic steatohepatitis, is a growing indication for liver transplantation in Europe, with good overall outcomes reported. However, careful risk factor assessment is required to maintain favourable post-transplant outcomes in patients with nonalcoholic steatohepatitis. (C) 2019 European Association for the Study of the Liver. Published by Elsevier B.V.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30219 - Gastroenterology and hepatology

Project

—

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of hepatology

ISSN

0168-8278

e-ISSN

—

Volume of the periodical

71

Issue of the periodical within the volume

2

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

10

Pages from-to

313-322

UT code for WoS article

000475462500014

EID of the result in the Scopus database

2-s2.0-85066258335