The number and phenotype of myocardial and adipose tissue CD68+ cells is associated with cardiovascular and metabolic disease in heart surgery patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00078224" target="_blank" >RIV/00023001:_____/19:00078224 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/19:10396489 RIV/00064165:_____/19:10396489

Result on the web

<a href="https://reader.elsevier.com/reader/sd/pii/S0939475319302133?token=4749186315B040DAF6ECF29D602BE5A227FAC824F608041B794164779D18B1B68059A2A831496091DE50AEBE9AE54EA5" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S0939475319302133?token=4749186315B040DAF6ECF29D602BE5A227FAC824F608041B794164779D18B1B68059A2A831496091DE50AEBE9AE54EA5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.numecd.2019.05.063" target="_blank" >10.1016/j.numecd.2019.05.063</a>

Result language

angličtina

Original language name

The number and phenotype of myocardial and adipose tissue CD68+ cells is associated with cardiovascular and metabolic disease in heart surgery patients

Original language description

Background and aims: CD68+ cells are a potent source of inflammatory cytokines in adipose tissue and myocardium. The development of low-grade inflammation in adipose tissue is implicated in the pathogenesis of obesity-associated disorders including type 2 diabetes mellitus (T2DM) and cardiovascular disease. The main aim of the study was to characterize and quantify myocardial and adipose tissue CD68+ cells and adipose tissue crown-like structures (CLS) in patients with obesity, coronary artery disease (CAD) and T2DM. Methods and results: Samples were obtained from the right atrium, epicardial (EAT) and subcutaneous adipose tissue (SAT) during elective heart surgery (non-obese, n = 34 patients; obese, n = 24 patients). Immunohistochemistry was used to visualize CD68+ cells. M1-polarized macrophages were visualized by immunohistochemical detection of CD11c. The proportion of CD68+ cells was higher in EAT than in SAT (43.4 +/- 25.0 versus 32.5 +/- 23.1 cells per 1 mm(2); p = 0.015). Myocardial CD68+ cells were more abundant in obese patients (45.6 +/- 24.5 versus 27.7 +/- 14.8 cells per 1 mm(2); p = 0.045). In SAT, CD68+ cells were more frequent in CAD patients (37.3 +/- 23.0 versus 23.1 +/- 20.9 cells per 1 mm(2); p = 0.012). Patients having CLS in their SAT had higher average BMI (34.1 +/- 6.4 versus 29.0 +/- 4.5; p = 0.024). Conclusions: Regional-based increases in the frequency of CD68+ cells and changes of their phenotype in CLS were detected in obese patients and CAD patients. Therapeutic modulation of adipose tissue inflammation may represent a target for treatment of obesity. (C) 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

<a href="/en/project/NV15-26854A" target="_blank" >NV15-26854A: The role of epicardial adipose tissue in heart disease: novel mechanisms of action and its therapeutic modulation</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nutrition, metabolism, and cardiovascular diseases

ISSN

0939-4753

e-ISSN

—

Volume of the periodical

29

Issue of the periodical within the volume

9

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

10

Pages from-to

946-955

UT code for WoS article

000478962200007

EID of the result in the Scopus database

2-s2.0-85068787562