New Adjusted Cutoffs for “Normal” Endocardial Voltages in Patients With Post-Infarct LV Remodeling
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00078515" target="_blank" >RIV/00023001:_____/19:00078515 - isvavai.cz</a>
Result on the web
<a href="https://www.jacc.org/doi/pdf/10.1016/j.jacep.2019.07.007" target="_blank" >https://www.jacc.org/doi/pdf/10.1016/j.jacep.2019.07.007</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jacep.2019.07.007" target="_blank" >10.1016/j.jacep.2019.07.007</a>
Alternative languages
Result language
angličtina
Original language name
New Adjusted Cutoffs for “Normal” Endocardial Voltages in Patients With Post-Infarct LV Remodeling
Original language description
Objectives: This study sought to determine new reference cutoffs for normal unipolar voltage (UV) and bipolar voltage (BV) that would be adjusted for the LV remodeling. Background: The definition of “normal” left ventricular (LV) endocardial voltage in patients with post-infarct scar is still lacking. The reference voltage of the noninfarcted myocardium (NIM) may differ between patients depending on LV structural remodeling and the ensuing interstitial fibrosis. Methods: Electroanatomic voltage mapping was integrated with isotropic late gadolinium–enhanced cardiac magnetic resonance in 15 patients with nonremodeled LV and 12 patients with remodeled LV (end-systolic volume index >50 ml/m2 with ejection fraction <47% assessed by cardiac magnetic resonance). Reference voltages (fifth percentile values) were determined from pooled NIM segments without late gadolinium enhancement. Results: The cutoffs for normal BV and UV were ≥3.0 and ≥6.7 mV for nonremodeled LV and ≥2.1 and ≥6.4 mV for remodeled LV. Endocardial low-voltage area (LVA) defined by the adjusted cutoffs corresponded better to late gadolinium enhancement–detected scar than did LVA defined by uniform cutoffs. In 15 patients who underwent successful ablation of ventricular tachycardia, the LVA contained >97% of targeted evoked delayed potentials. Insights from whole-heart T1 mapping revealed more fibrotic NIM in patients with remodeled LV compared with nonremodeled LV. Conclusions: This study found substantial differences in endocardial voltage of NIM in post-infarct patients with remodeled versus nonremodeled LV. The new adjusted cutoffs for “normal” BV and UV enable a patient-tailored approach to electroanatomic voltage mapping of LV. © 2019 American College of Cardiology Foundation
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
JACC : Clinical electrophysiology
ISSN
2405-5018
e-ISSN
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Volume of the periodical
5
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
1115-1126
UT code for WoS article
000602734900002
EID of the result in the Scopus database
2-s2.0-85073117165