Baseline Leptin/Adiponectin Ratio is a Significant Predictor of BMI Changes in Children/Adolescents after Intensive Lifestyle Intervention

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00078649" target="_blank" >RIV/00023001:_____/19:00078649 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/19:10401092 RIV/00064165:_____/19:10401092

Result on the web

<a href="https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-0859-7041" target="_blank" >https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-0859-7041</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1055/a-0859-7041" target="_blank" >10.1055/a-0859-7041</a>

Result language

angličtina

Original language name

Baseline Leptin/Adiponectin Ratio is a Significant Predictor of BMI Changes in Children/Adolescents after Intensive Lifestyle Intervention

Original language description

Introduction Abdominal obesity is a strong card iometabolic risk factor that often occurs as early as in childhood. The negative effect of abdominal obesity on the metabolism is partially mediated by changes to the production of the major adipocyte hormones leptin and adiponectin. Leptin/adiponectin imbalance is associated with increased risk of developing obesity and type 2 diabetes mellitus. Aim To determine whether leptin, adiponectin and the leptin/adiponectin ratio are significant predictors of body weight loss in intensively treated children/adolescents. Methods 183 paediatric overweight or obese patients (71 boys and 112 girls), aged 7-16 years, were enrolled in a one-month intensive lifestyle intervention programme. Participants reduced their energy intake and engaged in a supervised exercise programme consisting of 5 physical activity units per day. The subjects were examined both before and after the intervention. Results The mean BMI decrease achieved was -2.38 +/- 0.07 kg/m(2) (P &lt; 0.01). The decrease in plasma leptin concentration was - 16.59 +/- 0.84 ng/mL (P&lt;0.001) and CRP- 0.38 +/- 0.04 mg/L (P&lt;0.001). Changes in adiponectin concentrations were not statistically significant. The baseline leptin/adiponectin ratio was a significant predictor of decreases in body weight (P&lt;0.005), BMI (P&lt;0.0001) and waist circumference (P&lt;0.05). Conclusion The leptin/adiponectin ratio at baseline may be a useful predictor of results from interventions focused on decreasing BMIs in children/adolescents.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

<a href="/en/project/NV15-28876A" target="_blank" >NV15-28876A: Use of HTG gene score in diagnosis of primary hypertriglyceridemias and assessment of the risk of gastrointestinal and cardiovascular complications</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Experimental and clinical endocrinology &amp; diabetes

ISSN

0947-7349

e-ISSN

—

Volume of the periodical

127

Issue of the periodical within the volume

10

Country of publishing house

DE - GERMANY

Number of pages

6

Pages from-to

691-696

UT code for WoS article

000496758800007

EID of the result in the Scopus database

2-s2.0-85074545612