Body adiposity changes after lifestyle interventions in children/adolescents and the NYD-SP18 and TMEM18 variants
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F18%3A00077440" target="_blank" >RIV/00023001:_____/18:00077440 - isvavai.cz</a>
Result on the web
<a href="https://www.medscimonit.com/download/index/idArt/907180" target="_blank" >https://www.medscimonit.com/download/index/idArt/907180</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.12659/MSM.907180" target="_blank" >10.12659/MSM.907180</a>
Alternative languages
Result language
angličtina
Original language name
Body adiposity changes after lifestyle interventions in children/adolescents and the NYD-SP18 and TMEM18 variants
Original language description
Background: This study was carried out to determine the relationship between the common TMEM-18 (rs4854344, G>T) and NYD-SP18 (rs6971091, G>A) gene variants and weight loss after lifestyle interventions (increased physical activity in conjunction with optimal dietary intake) in overweight/obese children/adolescents. Material/Methods: We genotyped 684 unrelated, white, non-diabetic children (age 12.7 +/- 2.1 years, average BMI at baseline 30.66 +/- 4.80 kg/m(2)). Anthropometric and biochemical examinations were performed before and after 4 weeks of an intensive lifestyle intervention. Results: The mean weight Loss achieved was 5.20 +/- 2.02 kg (P<0.001). NYDSP-18 AA homozygotes had significantly higher abdominal skinfold value before and after the intervention (both, P=0.001). No significant associations between BMI decrease and the NYD-SP18 and TMEM18 variants were found. Associations between all anthropometrical and biochemical changes and genes remained non-significant after data were adjusted for sex, age, and baseline values. Conclusions: Decreased body weight in overweight/obese children is not significantly influenced by the NYD-SP18 rs6971091 or TMEM18 rs4854344 polymorphisms.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Medical science monitor
ISSN
1234-1010
e-ISSN
—
Volume of the periodical
24
Issue of the periodical within the volume
October 20
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
7493-7498
UT code for WoS article
000447722800003
EID of the result in the Scopus database
2-s2.0-85055204969