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Body adiposity changes after lifestyle interventions in children/adolescents and the NYD-SP18 and TMEM18 variants

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F18%3A00077440" target="_blank" >RIV/00023001:_____/18:00077440 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.medscimonit.com/download/index/idArt/907180" target="_blank" >https://www.medscimonit.com/download/index/idArt/907180</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.12659/MSM.907180" target="_blank" >10.12659/MSM.907180</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Body adiposity changes after lifestyle interventions in children/adolescents and the NYD-SP18 and TMEM18 variants

  • Original language description

    Background: This study was carried out to determine the relationship between the common TMEM-18 (rs4854344, G&gt;T) and NYD-SP18 (rs6971091, G&gt;A) gene variants and weight loss after lifestyle interventions (increased physical activity in conjunction with optimal dietary intake) in overweight/obese children/adolescents. Material/Methods: We genotyped 684 unrelated, white, non-diabetic children (age 12.7 +/- 2.1 years, average BMI at baseline 30.66 +/- 4.80 kg/m(2)). Anthropometric and biochemical examinations were performed before and after 4 weeks of an intensive lifestyle intervention. Results: The mean weight Loss achieved was 5.20 +/- 2.02 kg (P&lt;0.001). NYDSP-18 AA homozygotes had significantly higher abdominal skinfold value before and after the intervention (both, P=0.001). No significant associations between BMI decrease and the NYD-SP18 and TMEM18 variants were found. Associations between all anthropometrical and biochemical changes and genes remained non-significant after data were adjusted for sex, age, and baseline values. Conclusions: Decreased body weight in overweight/obese children is not significantly influenced by the NYD-SP18 rs6971091 or TMEM18 rs4854344 polymorphisms.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30202 - Endocrinology and metabolism (including diabetes, hormones)

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Medical science monitor

  • ISSN

    1234-1010

  • e-ISSN

  • Volume of the periodical

    24

  • Issue of the periodical within the volume

    October 20

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    6

  • Pages from-to

    7493-7498

  • UT code for WoS article

    000447722800003

  • EID of the result in the Scopus database

    2-s2.0-85055204969