All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

FTO and MC4R gene variants determine BMI changes in children after intensive lifestyle intervention

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10173488" target="_blank" >RIV/00216208:11110/13:10173488 - isvavai.cz</a>

  • Alternative codes found

    RIV/00023001:_____/13:00058549 RIV/00064165:_____/13:10173488

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.clinbiochem.2012.11.017" target="_blank" >http://dx.doi.org/10.1016/j.clinbiochem.2012.11.017</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.clinbiochem.2012.11.017" target="_blank" >10.1016/j.clinbiochem.2012.11.017</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    FTO and MC4R gene variants determine BMI changes in children after intensive lifestyle intervention

  • Original language description

    Objectives: This study aimed to determine whether there is a relationship between common FTO (rs17817449) and MC4R (rs17782313) gene variants and body mass reduction or weight loss after a one-month lifestyle intervention in overweight/obese children. Design and methods: We genotyped 357 unrelated non-diabetic Czech children (age 13.7 +/- 4.9 years, average BMI at baseline 30.8 +/- 4.6 kg/m(2)). Biochemical and anthropometrical measurements were performed before and after 4 weeks of lifestyle interventions (comprising a reduction in energy intake to the age-matched optimum and a supervised exercise program consisting of 5 exercise units per day, 50 min each). Results: The mean weight loss achieved was 6.2 +/- 2.1 kg (P<0.001). Significant associationswere found between a BMI decrease and the FTO and MC4R variants. Carriers of the FTO GG genotype and/or MC4R CC genotype lost significantly more body weight compared to noncarriers (P<0.0009 for BMI and P<0.002 for body weight). These dif

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FA - Cardiovascular diseases including cardio-surgery

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/NS10589" target="_blank" >NS10589: Genetic and factors of life style by children with metabolic syndrom and their dependents. Diagnostic and interference.</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2013

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Clinical Biochemistry

  • ISSN

    0009-9120

  • e-ISSN

  • Volume of the periodical

    46

  • Issue of the periodical within the volume

    4-5

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    4

  • Pages from-to

    313-316

  • UT code for WoS article

    000315661700007

  • EID of the result in the Scopus database