FTO and MC4R gene variants determine BMI changes in children after intensive lifestyle intervention
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10173488" target="_blank" >RIV/00216208:11110/13:10173488 - isvavai.cz</a>
Alternative codes found
RIV/00023001:_____/13:00058549 RIV/00064165:_____/13:10173488
Result on the web
<a href="http://dx.doi.org/10.1016/j.clinbiochem.2012.11.017" target="_blank" >http://dx.doi.org/10.1016/j.clinbiochem.2012.11.017</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.clinbiochem.2012.11.017" target="_blank" >10.1016/j.clinbiochem.2012.11.017</a>
Alternative languages
Result language
angličtina
Original language name
FTO and MC4R gene variants determine BMI changes in children after intensive lifestyle intervention
Original language description
Objectives: This study aimed to determine whether there is a relationship between common FTO (rs17817449) and MC4R (rs17782313) gene variants and body mass reduction or weight loss after a one-month lifestyle intervention in overweight/obese children. Design and methods: We genotyped 357 unrelated non-diabetic Czech children (age 13.7 +/- 4.9 years, average BMI at baseline 30.8 +/- 4.6 kg/m(2)). Biochemical and anthropometrical measurements were performed before and after 4 weeks of lifestyle interventions (comprising a reduction in energy intake to the age-matched optimum and a supervised exercise program consisting of 5 exercise units per day, 50 min each). Results: The mean weight loss achieved was 6.2 +/- 2.1 kg (P<0.001). Significant associationswere found between a BMI decrease and the FTO and MC4R variants. Carriers of the FTO GG genotype and/or MC4R CC genotype lost significantly more body weight compared to noncarriers (P<0.0009 for BMI and P<0.002 for body weight). These dif
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NS10589" target="_blank" >NS10589: Genetic and factors of life style by children with metabolic syndrom and their dependents. Diagnostic and interference.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical Biochemistry
ISSN
0009-9120
e-ISSN
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Volume of the periodical
46
Issue of the periodical within the volume
4-5
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
4
Pages from-to
313-316
UT code for WoS article
000315661700007
EID of the result in the Scopus database
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