Innate lymphoid cells play a pathogenic role in pericarditis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F20%3A00079453" target="_blank" >RIV/00023001:_____/20:00079453 - isvavai.cz</a>
Result on the web
<a href="https://reader.elsevier.com/reader/sd/pii/S2211124720302011?token=ECD1534F4BD788E8F295C1CA757A8D5DF563DC462093D3A6957BF9CB74AA1EB8232A81A0DD1C2F6B554B4679B64A61A4" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S2211124720302011?token=ECD1534F4BD788E8F295C1CA757A8D5DF563DC462093D3A6957BF9CB74AA1EB8232A81A0DD1C2F6B554B4679B64A61A4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.celrep.2020.02.040" target="_blank" >10.1016/j.celrep.2020.02.040</a>
Alternative languages
Result language
angličtina
Original language name
Innate lymphoid cells play a pathogenic role in pericarditis
Original language description
We find that cardiac group 2 innate lymphoid cells (ILC2s) are essential for the development of IL-33-induced eosinophilic pericarditis. We show a pathogenic role for ILC2s in cardiac inflammation, in which ILC2s activated by IL-33 drive the development of eosinophilic pericarditis in collaboration with cardiac fibroblasts. ILCs, not T and B cells, are required for the development of pericarditis. ILC2s transferred to the heart of Rag2(-/-)II2rg(-/-) mice restore their susceptibility to eosinophil infiltration. Moreover, ILC2s direct cardiac fibroblasts to produce eotaxin-1. We also find that eosinophils reside in the mediastinal cavity and that eosinophils transferred to the mediastinal cavity of eosinophil-deficient Delta dblGATA1 mice following IL-33 treatment migrate to the heart. Thus, the serous cavities may serve as a reservoir of cardiac-infiltrating eosinophils. In humans, patients with pericarditis show higher amounts of ILCs in pericardial fluid than do healthy controls and patients with other cardiac diseases. We demonstrate that ILCs play a critical role in pericarditis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
—
Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cell Reports
ISSN
2211-1247
e-ISSN
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Volume of the periodical
30
Issue of the periodical within the volume
9
Country of publishing house
US - UNITED STATES
Number of pages
21
Pages from-to
2989-"3003.e6"
UT code for WoS article
000517773300012
EID of the result in the Scopus database
2-s2.0-85080150988