Up-Regulation of CD163 Expression in Subpopulations of Blood Monocytes After Kidney Allograft Transplantation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F20%3A00080438" target="_blank" >RIV/00023001:_____/20:00080438 - isvavai.cz</a>
Result on the web
<a href="https://www.biomed.cas.cz/physiolres/pdf/2020/69_885.pdf" target="_blank" >https://www.biomed.cas.cz/physiolres/pdf/2020/69_885.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.33549/physiolres.934531" target="_blank" >10.33549/physiolres.934531</a>
Alternative languages
Result language
angličtina
Original language name
Up-Regulation of CD163 Expression in Subpopulations of Blood Monocytes After Kidney Allograft Transplantation
Original language description
M2 macrophages expressing CD163 are known to suppress immune responses but have been also found in biopsies of patients with chronic kidney allograft injury associated with interstitial fibrosis. The aim of our study was to evaluate the expression of CD163 in blood monocytes, precursors of tissue macrophages, in kidney allograft recipients with uncomplicated outcome (n=94) compared with those developing acute rejection (n=44). Blood samples were collected before the transplantation and at 1 week, 1 month and 1 year. The expression of CD163 increased during the first week after the transplantation not only in classical (CD14(+)CD16(-)) but also in intermediate (CD14(+)CD16(+)) and nonclassical (CD14(low)CD16(+)) monocytes in all patients regardless of their rejection status. In patients developing acute rejection, higher pre-transplant expression of CD163 on blood monocytes was found. In vitro experiments confirmed strong induction of membrane CD163 on monocytes together with CD206 (an alternative marker of M2 macrophages) in response to IL-10. We assume from our data that dramatic upregulation of CD163 by peripheral blood monocytes may have a pathophysiological role in early phases after kidney allograft transplantation and high pre-transplant expression of CD163 on blood monocytes might be involved in events leading to acute rejection.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30213 - Transplantation
Result continuities
Project
<a href="/en/project/NV15-26883A" target="_blank" >NV15-26883A: Regulatory mechanisms of innate immune cells in kidney transplantation</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physiological research
ISSN
0862-8408
e-ISSN
—
Volume of the periodical
69
Issue of the periodical within the volume
5
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
12
Pages from-to
885-896
UT code for WoS article
000591193000012
EID of the result in the Scopus database
2-s2.0-85096347711