Prediction of long-term prognosis of age-related macular degeneration treated by hemorheologic therapy using baseline laboratory indicators - Experimental-clinical model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F20%3A00080738" target="_blank" >RIV/00023001:_____/20:00080738 - isvavai.cz</a>
Alternative codes found
RIV/00179906:_____/20:10421828 RIV/00216208:11150/20:10421828
Result on the web
<a href="https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch209101" target="_blank" >https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch209101</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3233/CH-209101" target="_blank" >10.3233/CH-209101</a>
Alternative languages
Result language
angličtina
Original language name
Prediction of long-term prognosis of age-related macular degeneration treated by hemorheologic therapy using baseline laboratory indicators - Experimental-clinical model
Original language description
BACKGROUND + OBJECTIVE: Age-related macular degeneration (AMD) is the most common cause of practical blindness in people over 60 years of age in industrialised countries. We formulated a hypothesis that a group of initial laboratory parameters would be suitable for prediction of prognosis of AMD, allowing for individual modifications in treatment intensity. PATIENTS AND METHODS: 66 patients with dry form of AMD were treated using rheohaemapheresis with an individual follow-up period of more than 5 years. The patients' initial laboratory data was split in two subgroups based on treatment success and analysed using discriminant analysis (analysis of the linear and quadratic models using the automated and interactive step-wise approach) by means of the Systat 13 software. RESULTS: Prediction of prognosis based on the initial laboratory parameters was correct in 79% of unsuccessfully treated patients, allowing for early detection of high-risk patients. With the use of a quadratic model, the prediction was correct in 100% of unsuccessfully treated patients and in 75% of successfully treated patients. CONCLUSION: Implementation of discriminant analysis is a promising method for prediction of prognosis, especially when the patient is at risk of AMD progression, which allows for early and more intensive monitoring and treatment.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30205 - Hematology
Result continuities
Project
<a href="/en/project/NV17-29241A" target="_blank" >NV17-29241A: Proprotein convertase subtilisin/kexin 9 (PCSK9) in the pathophysiology a treatment of dry age-related macular degeneration</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical hemorheology and microcirculation
ISSN
1386-0291
e-ISSN
—
Volume of the periodical
76
Issue of the periodical within the volume
4
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
11
Pages from-to
573-583
UT code for WoS article
000610843900011
EID of the result in the Scopus database
2-s2.0-85099598569