Increased heart rate with sleep disordered breathing in hypertrophic cardiomyopathy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00080634" target="_blank" >RIV/00023001:_____/21:00080634 - isvavai.cz</a>

Alternative codes found

RIV/65269705:_____/21:00075307 RIV/00216224:14110/21:00124274

Result on the web

<a href="https://reader.elsevier.com/reader/sd/pii/S0167527320335476?token=54D3A80D64471720FAD8AABD86E10619966458AB1656D20E9953E0119F6652CFABB40BB4FD04DF76335B54B8056D06EC" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S0167527320335476?token=54D3A80D64471720FAD8AABD86E10619966458AB1656D20E9953E0119F6652CFABB40BB4FD04DF76335B54B8056D06EC</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijcard.2020.08.020" target="_blank" >10.1016/j.ijcard.2020.08.020</a>

Result language

angličtina

Original language name

Increased heart rate with sleep disordered breathing in hypertrophic cardiomyopathy

Original language description

Background: Current guidelines recommend medications with rate control properties for symptomatic patients with hypertrophic cardiomyopathy (HCM) based on the rationale that lowering heart rate (HR) improves their symptoms. Whether sleep disordered breathing (SDB) is associated with increased HR in HCM patients is not known. Method: We diagnosed uncontrolled SDB (oxygen desaturation index ≥5) in consecutive echocardiographically confirmed HCM patients seen at Mayo Clinic, Rochester, and analyzed their HR as recorded by a 24-h Holter monitor. We compared mean, minimum, maximum HR between those with vs without SDB. In a pilot subanalysis of HCM patients with SDB who also underwent subsequent diagnostic polysomnography (PSG), we analyzed RR interval changes coinciding with obstructive sleep apnea and hypopnea episodes. Results: Of the 230 HCM patients included in this study (age 54 ± 16 years; 138 male; LVOT pressure gradient at rest 45 ± 39 mmHg), 115 (50%) patients had SDB. HCM patients with SDB were recorded to have higher mean HR (71 vs. 67 bpm; p =.002, adjusted p =.001), and this difference was most pronounced during night hours of 10 PM to 5 AM (61 vs. 67 bpm; p &lt;.001). In the pilot analysis of the available PSG data, the release of obstructive sleep apneas and hypopneas coincided with fluctuation of HR. Conclusions: SDB is independently associated with higher mean HR in patients with HCM, and this difference is most significant during sleep. Treatment of SDB, which is readily available, should be tested as a complementary modality to the currently recommended pharmacotherapy aimed at lowering HR in patients with symptomatic HCM. © 2020

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

—

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International journal of cardiology

ISSN

0167-5273

e-ISSN

—

Volume of the periodical

323

Issue of the periodical within the volume

January

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

6

Pages from-to

155-160

UT code for WoS article

000599599700034

EID of the result in the Scopus database

2-s2.0-85090305199