Changes in Sepsis Biomarkers after Immunosuppressant Administration in Transplant Patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00080761" target="_blank" >RIV/00023001:_____/21:00080761 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/21:43921078 RIV/00216208:11110/21:10421862

Result on the web

<a href="https://downloads.hindawi.com/journals/mi/2021/8831659.pdf" target="_blank" >https://downloads.hindawi.com/journals/mi/2021/8831659.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2021/8831659" target="_blank" >10.1155/2021/8831659</a>

Result language

angličtina

Original language name

Changes in Sepsis Biomarkers after Immunosuppressant Administration in Transplant Patients

Original language description

Sepsis biomarkers change continuously during the postoperative period. We aimed to demonstrate the influence of immunosuppressants after transplantation (Tx) on presepsin, procalcitonin, CRP, white blood cells, and IL-6. A group of 140 patients after major surgery (86 non-Tx, 54 Tx) without any signs of sepsis or infectious complications was followed for 7 days. The changes in biomarkers were analyzed with respect to the type of surgery, organ, and induction immunosuppressant used (antithymocyte globulin, corticosteroids, or basiliximab/rituximab). Concentrations (95th percentiles) of presepsin and procalcitonin were higher in the Tx group (presepsin: Tx&lt;2380 vs. non-Tx&lt;1368 ng/L, p&lt;0.05; procalcitonin: &lt;28.0 vs. 3.49 μg/L, p&lt;0.05). In contrast, CRP and IL-6 were lower in the Tx group (CRP: Tx&lt;84.2 vs. non-Tx&lt;229 mg/L, p&lt;0.05; IL-6: &lt;71.2 vs. 317 ng/L, p&lt;0.05). Decreases in CRP and IL-6 were found for all immunosuppressants, and procalcitonin was increased after antithymocyte globulin and corticosteroids. Negligible changes were found for white blood cells. Different responses of presepsin, procalcitonin, CRP, and IL-6 were therefore found in patients without any infectious complications after major surgery or transplantation. Immunosuppression decreased significantly IL-6 and CRP in comparison to non-Tx patients, while procalcitonin was increased after corticosteroids and antithymocyte globulin only. Cautious interpretation of sepsis biomarkers is needed in the early posttransplant period. This work was conducted as a noninterventional (nonregistered) study. © 2021 Janka Franeková et al.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30213 - Transplantation

Project

<a href="/en/project/NV15-27579A" target="_blank" >NV15-27579A: Monoclonal gammopathies in solid organ transplant recipients. Relationship between posttransplant immunosuppression and lymphoproliferative diseases.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Mediators of inflammation [online]

ISSN

0962-9351

e-ISSN

—

Volume of the periodical

2021

Issue of the periodical within the volume

Januar

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

"art. no. 8831659"

UT code for WoS article

000612237700002

EID of the result in the Scopus database

2-s2.0-85099617370