Serial measurement of presepsin, procalcitonin, and C-reactive protein in the early postoperative period and the response to antithymocyte globulin administration after heart transplantation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F17%3A43912361" target="_blank" >RIV/00216208:11120/17:43912361 - isvavai.cz</a>
Alternative codes found
RIV/00023001:_____/17:00060199
Result on the web
<a href="http://dx.doi.org/10.1111/ctr.12870" target="_blank" >http://dx.doi.org/10.1111/ctr.12870</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/ctr.12870" target="_blank" >10.1111/ctr.12870</a>
Alternative languages
Result language
angličtina
Original language name
Serial measurement of presepsin, procalcitonin, and C-reactive protein in the early postoperative period and the response to antithymocyte globulin administration after heart transplantation
Original language description
Differentiation between systemic inflammatory response syndrome (SIRS) and sepsis in surgical patients is of crucial significance. Procalcitonin (PCT) and C-reactive protein (CRP) are widely used biomarkers, but PCT becomes compromised after antithymocyte globulin (ATG) administration, and CRP exhibits limited specificity. Presepsin has been suggested as an alternative biomarker of sepsis. This study aims to demonstrate the role of presepsin in patients after heart transplantation (HTx). Plasma presepsin, PCT and CRP were measured in 107 patients serially for up to 10 days following HTx. Time responses of biomarkers were evaluated for both noninfected (N=91) and infected (N=16) patients. Areas under the concentration curve (AUC) differed in the two groups of patients for presepsin (p<0.001), PCT (p<0.005) and CRP (p<0.001). The effect of time and infection was significant for all three biomarkers (p<0.05 all). In contrast to PCT, presepsin was not influenced by ATG administration. More than 25% of noninfected patients had PCT above 42 μg/L on the 1(st) day and the peak concentration of CRP in infected patients was reached on the 3(rd) posttransplant day (median 135 mg/L). Presepsin seems to be as valuable a biomarker as PCT or CRP in the evaluation of infectious complications in patients after HTx.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
<a href="/en/project/NV15-27579A" target="_blank" >NV15-27579A: Monoclonal gammopathies in solid organ transplant recipients. Relationship between posttransplant immunosuppression and lymphoproliferative diseases.</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical Transplantation
ISSN
0902-0063
e-ISSN
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Volume of the periodical
31
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
"e12870"
UT code for WoS article
000392436100010
EID of the result in the Scopus database
2-s2.0-85006415898