Myristic acid serum levels and their significance for diagnosis of systemic inflammatory response, sepsis, and bacteraemia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00080951" target="_blank" >RIV/00023001:_____/21:00080951 - isvavai.cz</a>

Alternative codes found

RIV/00064190:_____/21:N0000078 RIV/00216208:11110/21:10428078

Result on the web

<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074080/pdf/jpm-11-00306.pdf" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074080/pdf/jpm-11-00306.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/jpm11040306" target="_blank" >10.3390/jpm11040306</a>

Result language

angličtina

Original language name

Myristic acid serum levels and their significance for diagnosis of systemic inflammatory response, sepsis, and bacteraemia

Original language description

Myristic acid is identified as a metabolite with the highest diagnostic sensitivity and specificity in the metabolome of patients with bacteraemia. Its significant decrease has been observed in patients with septic shock not responding to treatment. Another study has reported a close correlation of myristic acid levels with the outcome of severe trauma patients. Myristic acid concentrations were investigated in a cohort of septic patients and patients with Systemic Inflammatory Response Syndrome (SIRS) in 5 consecutive days following diagnosis and compared to healthy controls. The study population groups—Sepsis 34, SIRS 31, and Healthy Control 120 patients were included. Serum samples were analyzed using gas chromatography and mass spectrometry. The myristic acid levels in the Sepsis Group and SIRS Group were found to be significantly higher when compared to healthy controls. The serum concentration of myristic acid in septic patients with bacteraemia was higher than in septic patients without bacteraemia. Most patients with sepsis and SIRS had the highest levels of myristic acid within 24 h after an established diagnosis. Myristic acid should be considered as a new candidate marker of severe inflammation and sepsis. A simplified analysis and sufficient body of validated data are necessary steps towards the introduction of this metabolite into routine clinical practice.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30218 - General and internal medicine

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of personalized medicine

ISSN

2075-4426

e-ISSN

—

Volume of the periodical

11

Issue of the periodical within the volume

4

Country of publishing house

CH - SWITZERLAND

Number of pages

15

Pages from-to

"art. no. 306"

UT code for WoS article

000643110500001

EID of the result in the Scopus database

2-s2.0-85105296944