Kinetics of Myristic Acid Following Accidentally Induced Septic Response
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F19%3A00555145" target="_blank" >RIV/60162694:G44__/19:00555145 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/19:10401478 RIV/00023884:_____/19:00008606 RIV/00064190:_____/19:N0000115
Result on the web
<a href="https://pmr.lf1.cuni.cz/120/2/0103/" target="_blank" >https://pmr.lf1.cuni.cz/120/2/0103/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.14712/23362936.2019.15" target="_blank" >10.14712/23362936.2019.15</a>
Alternative languages
Result language
angličtina
Original language name
Kinetics of Myristic Acid Following Accidentally Induced Septic Response
Original language description
Myristic acid was identified as a metabolite with the highest diagnostic sensitivity and specificity in the metabolome of patients with bacteraemia. Subsequently, its significant decrease was observed in patients in septic shock not responding to treatment. In our study we have captured myristic acid serum level kinetics in 96 hours following accidental intravenous self-administration of eubiotic Hylak forte causing infection-like systemic inflammatory response syndrome (SIRS). To our knowledge, this is the first time the kinetics of myristic acid levels is presented in a septic patient. Myristic acid was evaluated in comparison with other inflammatory biomarkers and with its level in a control group of healthy subjects. Myristic acid levels during septic response were significantly elevated in comparison with the control group. The peak level was recorded almost immediately after the insult with a gradual decrease within 96 hours. Myristic acid appears to be a promising biomarker in sepsis diagnostics, further research by our group into this topic is ongoing.
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Prague Medical Report
ISSN
1214-6994
e-ISSN
2336-2936
Volume of the periodical
120
Issue of the periodical within the volume
2-3
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
4
Pages from-to
103-106
UT code for WoS article
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EID of the result in the Scopus database
2-s2.0-85072977213