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Kinetics of Myristic Acid Following Accidentally Induced Septic Response

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F19%3A00555145" target="_blank" >RIV/60162694:G44__/19:00555145 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11110/19:10401478 RIV/00023884:_____/19:00008606 RIV/00064190:_____/19:N0000115

  • Result on the web

    <a href="https://pmr.lf1.cuni.cz/120/2/0103/" target="_blank" >https://pmr.lf1.cuni.cz/120/2/0103/</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.14712/23362936.2019.15" target="_blank" >10.14712/23362936.2019.15</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Kinetics of Myristic Acid Following Accidentally Induced Septic Response

  • Original language description

    Myristic acid was identified as a metabolite with the highest diagnostic sensitivity and specificity in the metabolome of patients with bacteraemia. Subsequently, its significant decrease was observed in patients in septic shock not responding to treatment. In our study we have captured myristic acid serum level kinetics in 96 hours following accidental intravenous self-administration of eubiotic Hylak forte causing infection-like systemic inflammatory response syndrome (SIRS). To our knowledge, this is the first time the kinetics of myristic acid levels is presented in a septic patient. Myristic acid was evaluated in comparison with other inflammatory biomarkers and with its level in a control group of healthy subjects. Myristic acid levels during septic response were significantly elevated in comparison with the control group. The peak level was recorded almost immediately after the insult with a gradual decrease within 96 hours. Myristic acid appears to be a promising biomarker in sepsis diagnostics, further research by our group into this topic is ongoing.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database

  • CEP classification

  • OECD FORD branch

    30102 - Immunology

Result continuities

  • Project

  • Continuities

    V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Prague Medical Report

  • ISSN

    1214-6994

  • e-ISSN

    2336-2936

  • Volume of the periodical

    120

  • Issue of the periodical within the volume

    2-3

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    4

  • Pages from-to

    103-106

  • UT code for WoS article

  • EID of the result in the Scopus database

    2-s2.0-85072977213