Antifouling fluoropolymer-coated nanomaterials for F-19 MRI

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00081029" target="_blank" >RIV/00023001:_____/21:00081029 - isvavai.cz</a>
Alternative codes found
RIV/46747885:24530/21:00009445
Result on the web
<a href="https://pubs.rsc.org/en/content/articlelanding/2021/CC/D1CC00642H#!divAbstract" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2021/CC/D1CC00642H#!divAbstract</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/d1cc00642h" target="_blank" >10.1039/d1cc00642h</a>

Result language
angličtina
Original language name
Antifouling fluoropolymer-coated nanomaterials for F-19 MRI
Original language description
We developed a multifunctional polymer coating for nanoparticles (NPs) that enables simultaneous detection by F-19 MRI and shielding from blood plasma fouling. The coating is based on a water-soluble fluorinated poly(N-(2-fluoroethyl)acrylamide) (PFEAM) that shows high F-19 MRI sensitivity, cytocompatibility and excellent antifouling properties, significantly outperforming polyethylene glycol. A proof-of-concept experiment was performed by synthesizing polymer-coated gold NPs that were successfully visualized by F-19 MRI at magnetic fields close to the fields used in clinical practice. This universal approach can be used for coating and tracing of various NPs upon suitable polymer chain-end modification.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30107 - Medicinal chemistry

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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