Frontiers in F-19-MR imaging : nanofluorides and F-19-CEST as novel extensions to the F-19-MRI toolbox

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F23%3A00083984" target="_blank" >RIV/00023001:_____/23:00083984 - isvavai.cz</a>
Result on the web
<a href="https://pubs.rsc.org/en/content/articlepdf/2023/cc/d3cc00562c" target="_blank" >https://pubs.rsc.org/en/content/articlepdf/2023/cc/d3cc00562c</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/d3cc00562c" target="_blank" >10.1039/d3cc00562c</a>

Result language
angličtina
Original language name
Frontiers in F-19-MR imaging : nanofluorides and F-19-CEST as novel extensions to the F-19-MRI toolbox
Original language description
Fluorine-containing materials have enriched the field of molecular and cellular MRI with unambiguous and quantitative detection capabilities. The background-free "hot-spot" display and the large range of chemical shifts of the broad palette of F-19-formulations are now used for a variety of applications. The common features of these formulations are: (i) they are based on organic molecular backbones (i.e., organofluorines); and (ii) their F-19-MRI detectability relies on a well-defined and clearly observed F-19-MR signal. During the last few years, our lab aimed to expand the F-19-MR toolbox with new capabilities that were, thus far, not used in molecular and cellular F-19-MRI. This Feature Article summarizes our developments and implementations in the field of F-19-MRI emphasizing (i) the introduction of ultrasmall inorganic fluoride-based nanocrystals (nanofluorides) as nano-sized (<10 nm) agents for F-19-MRI, and (ii) the use of Chemical Exchange Saturation Transfer (CEST) in the F-19-MRI framework to indirectly amplify F-19-MR signals of otherwise-undetected fluorinated entities.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30224 - Radiology, nuclear medicine and medical imaging

Project
<a href="/en/project/GN22-13334I" target="_blank" >GN22-13334I: Genetically-engineered extracellular vesicles as novel imaging and therapeutical probes for specific targeting of tumors</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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