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ACE I/D polymorphism in Czech first-wave SARS-CoV-2-positive survivors

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00081143" target="_blank" >RIV/00023001:_____/21:00081143 - isvavai.cz</a>

  • Alternative codes found

    RIV/68407700:21460/21:00357387 RIV/00216224:14110/21:00121855

  • Result on the web

    <a href="https://reader.elsevier.com/reader/sd/pii/S0009898121001492?token=283ED33899916EABDFDE0226449A3E7CAC3DC2C945AF5D35DBF3E4DC9AD9035C6F9C8007DBCC21FCA3778B3F721F2EE2&originRegion=eu-west-1&originCreation=20210728102456" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S0009898121001492?token=283ED33899916EABDFDE0226449A3E7CAC3DC2C945AF5D35DBF3E4DC9AD9035C6F9C8007DBCC21FCA3778B3F721F2EE2&originRegion=eu-west-1&originCreation=20210728102456</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.cca.2021.04.024" target="_blank" >10.1016/j.cca.2021.04.024</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    ACE I/D polymorphism in Czech first-wave SARS-CoV-2-positive survivors

  • Original language description

    Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly spread from China in 2019/ 2020 to all continents. Significant geographical and ethnic differences were described, and host genetic background seems to be important for the resistance to and mortality of COVID-19. Angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism (rs4646994) is one of the candidates with the potential to affect infection symptoms and mortality. Methods: In our study, we successfully genotyped 408 SARS-CoV-2-positive COVID-19 survivors (163 asymptomatic and 245 symptomatic) and compared them with a population-based DNA bank of 2,559 subjects. Results: The frequency of ACE I/I homozygotes was significantly increased in COVID-19 patients compared with that in controls (26.2% vs. 21.2%; P = 0.02; OR [95% CI] = 1.55 [1.17-2.05]. Importantly, however, the difference was driven just by the symptomatic subjects (29.0% vs. 21.2% of the I/I homozygotes; P = 0.002; OR [95% CI] = 1.78 [1.22-2.60]). The genotype distribution of the ACE genotypes was almost identical in population controls and asymptomatic SARS-CoV-2-positive patients (P = 0.76). Conclusions: We conclude that ACE I/D polymorphism could have the potential to predict the severity of COVID19, with I/I homozygotes being at increased risk of symptomatic COVID-19.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30303 - Infectious Diseases

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Clinica chimica acta

  • ISSN

    0009-8981

  • e-ISSN

  • Volume of the periodical

    519

  • Issue of the periodical within the volume

    August

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    4

  • Pages from-to

    206-209

  • UT code for WoS article

    000659205000008

  • EID of the result in the Scopus database

    2-s2.0-85106338177