ACE I/D polymorphism in Czech first-wave SARS-CoV-2-positive survivors
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00081143" target="_blank" >RIV/00023001:_____/21:00081143 - isvavai.cz</a>
Alternative codes found
RIV/68407700:21460/21:00357387 RIV/00216224:14110/21:00121855
Result on the web
<a href="https://reader.elsevier.com/reader/sd/pii/S0009898121001492?token=283ED33899916EABDFDE0226449A3E7CAC3DC2C945AF5D35DBF3E4DC9AD9035C6F9C8007DBCC21FCA3778B3F721F2EE2&originRegion=eu-west-1&originCreation=20210728102456" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S0009898121001492?token=283ED33899916EABDFDE0226449A3E7CAC3DC2C945AF5D35DBF3E4DC9AD9035C6F9C8007DBCC21FCA3778B3F721F2EE2&originRegion=eu-west-1&originCreation=20210728102456</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cca.2021.04.024" target="_blank" >10.1016/j.cca.2021.04.024</a>
Alternative languages
Result language
angličtina
Original language name
ACE I/D polymorphism in Czech first-wave SARS-CoV-2-positive survivors
Original language description
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly spread from China in 2019/ 2020 to all continents. Significant geographical and ethnic differences were described, and host genetic background seems to be important for the resistance to and mortality of COVID-19. Angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism (rs4646994) is one of the candidates with the potential to affect infection symptoms and mortality. Methods: In our study, we successfully genotyped 408 SARS-CoV-2-positive COVID-19 survivors (163 asymptomatic and 245 symptomatic) and compared them with a population-based DNA bank of 2,559 subjects. Results: The frequency of ACE I/I homozygotes was significantly increased in COVID-19 patients compared with that in controls (26.2% vs. 21.2%; P = 0.02; OR [95% CI] = 1.55 [1.17-2.05]. Importantly, however, the difference was driven just by the symptomatic subjects (29.0% vs. 21.2% of the I/I homozygotes; P = 0.002; OR [95% CI] = 1.78 [1.22-2.60]). The genotype distribution of the ACE genotypes was almost identical in population controls and asymptomatic SARS-CoV-2-positive patients (P = 0.76). Conclusions: We conclude that ACE I/D polymorphism could have the potential to predict the severity of COVID19, with I/I homozygotes being at increased risk of symptomatic COVID-19.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30303 - Infectious Diseases
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinica chimica acta
ISSN
0009-8981
e-ISSN
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Volume of the periodical
519
Issue of the periodical within the volume
August
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
4
Pages from-to
206-209
UT code for WoS article
000659205000008
EID of the result in the Scopus database
2-s2.0-85106338177