Effects of Trandolapril on Structural, Contractile and Electrophysiological Remodeling in Experimental Volume Overload Heart Failure

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00081534" target="_blank" >RIV/00023001:_____/21:00081534 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/21:10432289 RIV/00216208:11140/21:10432289

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fphar.2021.729568/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fphar.2021.729568/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fphar.2021.729568" target="_blank" >10.3389/fphar.2021.729568</a>

Result language

angličtina

Original language name

Effects of Trandolapril on Structural, Contractile and Electrophysiological Remodeling in Experimental Volume Overload Heart Failure

Original language description

Chronic volume overload induces multiple cardiac remodeling processes that finally result in eccentric cardiac hypertrophy and heart failure. We have hypothesized that chronic angiotensin-converting enzyme (ACE) inhibition by trandolapril might affect various remodeling processes differentially, thus allowing their dissociation. Cardiac remodeling due to chronic volume overload and the effects of trandolapril were investigated in rats with an aortocaval fistula (ACF rats). The aortocaval shunt was created using a needle technique and progression of cardiac remodeling to heart failure was followed for 24 weeks. In ACF rats, pronounced eccentric cardiac hypertrophy and contractile and proarrhythmic electrical remodeling were associated with increased mortality. Trandolapril substantially reduced the electrical proarrhythmic remodeling and mortality, whereas the effect on cardiac hypertrophy was less pronounced and significant eccentric hypertrophy was preserved. Effective suppression of electrical proarrhythmic remodeling and mortality but not hypertrophy indicates that the beneficial therapeutic effects of ACE inhibitor trandolapril in volume overload heart failure might be dissociated from pure antihypertrophic effects.&lt;/p&gt;

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

<a href="/en/project/NU20-02-00052" target="_blank" >NU20-02-00052: Kidney and heart interaction in the pathophysiology of heart failure: translation studies to define new therapeutic targets</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in pharmacology [online]

ISSN

1663-9812

e-ISSN

—

Volume of the periodical

12

Issue of the periodical within the volume

September 10

Country of publishing house

CH - SWITZERLAND

Number of pages

13

Pages from-to

"art. no. 729568"

UT code for WoS article

000698860800001

EID of the result in the Scopus database

2-s2.0-85115712397