Outcome of 313 Czech Patients With IgA Nephropathy After Renal Transplantation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00081585" target="_blank" >RIV/00023001:_____/21:00081585 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/21:10433389 RIV/00064165:_____/21:10433389

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fimmu.2021.726215/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fimmu.2021.726215/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fimmu.2021.726215" target="_blank" >10.3389/fimmu.2021.726215</a>

Result language

angličtina

Original language name

Outcome of 313 Czech Patients With IgA Nephropathy After Renal Transplantation

Original language description

The recurrence of IgA nephropathy (IgAN) after kidney transplantation occurs in 20-35% of patients. The main aim of this study is to evaluate risk factors affecting the course of IgAN after renal biopsy of native kidney and kidney transplant. We evaluated clinical parameters and histological findings at the time of biopsy of native kidney and after kidney transplantation in 313 patients with IgAN with a follow-up of up to 36 years. Using hierarchical clustering method, patients with graft failure (n=50) were divided into two groups based on the mean time from kidney transplant to graft failure (11.2 versus 6.1 years). The time-to-graft failure corresponded well to the time from the renal biopsy of native kidney to end-stage renal disease (5.9 versus 0.4 years). Body mass index, proteinuria, microscopic hematuria, histological evaluation of fibrosis, and crescents at the time of renal biopsy of native kidney were the main variables for the differentiation of the two groups. Higher age of kidney-transplant donor, histological recurrence of IgAN, antibody-mediated rejection, and the onset of microscopic hematuria and proteinuria within 1 year after kidney transplant were also associated with worse graft survival in multivariate Cox regression analysis.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30213 - Transplantation

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in immunology [online]

ISSN

1664-3224

e-ISSN

—

Volume of the periodical

12

Issue of the periodical within the volume

September

Country of publishing house

CH - SWITZERLAND

Number of pages

9

Pages from-to

"art. no. 726215"

UT code for WoS article

000708980700001

EID of the result in the Scopus database

2-s2.0-85117094175