Does the renal expression of Toll-like receptors play a role in patients with IgA nephropathy?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F44555601%3A13520%2F19%3A43894923" target="_blank" >RIV/44555601:13520/19:43894923 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/20:10411869 RIV/00023001:_____/20:00079507 RIV/00023728:_____/20:N0000018 RIV/00064165:_____/20:10411869

Result on the web

<a href="https://link.springer.com/article/10.1007%2Fs40620-019-00640-z" target="_blank" >https://link.springer.com/article/10.1007%2Fs40620-019-00640-z</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s40620-019-00640-z" target="_blank" >10.1007/s40620-019-00640-z</a>

Result language

angličtina

Original language name

Does the renal expression of Toll-like receptors play a role in patients with IgA nephropathy?

Original language description

The onset of IgA nephropathy (IgAN), characterized by glomerular deposition of IgA-containing immune complexes, is often associated with synpharyngitic hematuria. Innate immune responses mediated by Toll-like receptors (TLR) may play a role in IgAN onset and/or progression. Here, we assessed the expression of TLR 4, 7, 8, and 9 in renal-biopsy specimens from patients with IgAN, with different degree of proteinuria and eGFR, compared with normal-kidney and disease-control tissues (ANCA-associated vasculitis). Renal-biopsy specimens from 34 patients with IgAN and 7 patients with ANCA-associated vasculitis were used. In addition, we used 15 healthy portions of renal-tissue specimens from kidneys after nephrectomy for cancer as control specimens. Expression of TLR 4, 7, 8, and 9 was assessed using immunohistochemical staining of paraffin-embedded renal-biopsy tissue specimens with specific antibodies and evaluated semiquantitatively by light microscopy. Linear discriminant analysis (LDA) was used to test whether intrarenal staining of TLR 4, 7, 8, and 9 distinguished patients with IgAN from controls or correlated with eGFR and/or proteinuria. eGFR was calculated using the creatinine-based formula. Moreover, the biopsies from patients with IgAN were scored according to the Oxford Classification. LDA showed that staining for TLR 4, 7, 8, and 9 was more intense in specimens from IgAN patients compared to normal kidney tissues. The intensity of intrarenal staining of TLRs discriminated four groups of IgAN patients with different eGFR and proteinuria and MEST scoring.

Czech name

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Czech description

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Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

—

OECD FORD branch

30217 - Urology and nephrology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Nephrology

ISSN

1121-8428

e-ISSN

—

Volume of the periodical

2019

Issue of the periodical within the volume

1

Country of publishing house

CH - SWITZERLAND

Number of pages

10

Pages from-to

1-10

UT code for WoS article

—

EID of the result in the Scopus database

2-s2.0-85073809837