Gut microbiota as the link between elevated BCAA serum levels and insulin resistance

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00081874" target="_blank" >RIV/00023001:_____/21:00081874 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/21:43922254 RIV/00064173:_____/21:N0000195
Result on the web
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533624/pdf/biomolecules-11-01414.pdf" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533624/pdf/biomolecules-11-01414.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/biom11101414" target="_blank" >10.3390/biom11101414</a>

Result language
angličtina
Original language name
Gut microbiota as the link between elevated BCAA serum levels and insulin resistance
Original language description
The microbiota-harboring human gut is an exquisitely active ecosystem that has evolved in a constant symbiosis with the human host. It produces numerous compounds depending on its metabolic capacity and substrates availability. Diet is the major source of the substrates that are metabolized to end-products, further serving as signal molecules in the microbiota-host cross-talk. Among these signal molecules, branched-chain amino acids (BCAAs) has gained significant scien-tific attention. BCAAs are abundant in animal-based dietary sources; they are both produced and degraded by gut microbiota and the host circulating levels are associated with the risk of type 2 diabetes. This review aims to summarize the current knowledge on the complex relationship between gut microbiota and its functional capacity to handle BCAAs as well as the host BCAA metabolism in insulin resistance development. Targeting gut microbiota BCAA metabolism with a dietary modulation could represent a promising approach in the prevention and treatment of insulin resistance related states, such as obesity and diabetes. © 2021 by the authors. Li-censee MDPI, Basel, Switzerland.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)

Project
<a href="/en/project/NV18-01-00040" target="_blank" >NV18-01-00040: Modification of gut microbiota in the treatment of insulin resistance: a personalized approach</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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