A Three-Arm Parallel-group Exploratory Trial documents balance improvement without much evidence of white matter integrity changes in people with multiple sclerosis following two months ambulatory neuroproprioceptive "facilitation and inhibition" physical therapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00081951" target="_blank" >RIV/00023001:_____/21:00081951 - isvavai.cz</a>
Alternative codes found
RIV/67985807:_____/21:00540731 RIV/00023752:_____/21:43920606 RIV/00216208:11120/21:43921107 RIV/00064203:_____/21:10423039 RIV/68407700:21230/21:00347455
Result on the web
<a href="https://www.minervamedica.it/en/getfreepdf/a1k4M0pzM2wvMXhnVTlnYS9sTDF2ditIQS95S2JEQTdLMVJUS0hRekNJWUVqWmlueHBOOUVCQkF3aVpRWGVDRA%253D%253D/R33Y2021N06A0889.pdf" target="_blank" >https://www.minervamedica.it/en/getfreepdf/a1k4M0pzM2wvMXhnVTlnYS9sTDF2ditIQS95S2JEQTdLMVJUS0hRekNJWUVqWmlueHBOOUVCQkF3aVpRWGVDRA%253D%253D/R33Y2021N06A0889.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.23736/S1973-9087.21.06701-0" target="_blank" >10.23736/S1973-9087.21.06701-0</a>
Alternative languages
Result language
angličtina
Original language name
A Three-Arm Parallel-group Exploratory Trial documents balance improvement without much evidence of white matter integrity changes in people with multiple sclerosis following two months ambulatory neuroproprioceptive "facilitation and inhibition" physical therapy
Original language description
BACKGROUND: Changes of white matter integrity in people with multiple sclerosis (MS) were documented following mainly motor/skill acquisitions physical therapy, while following neuroproprioceptive "facilitation, inhibition" (neurofacilitation) only by two pilot studies. Neurofacilitation has potential to induce white matter changes due to the possibility of interfering with the neuronal tactility threshold. However stronger evidence is missing. AIM: This study investigates whether neurofacilitation (three physical therapy types) induce white matter changes and if they relate to clinical improvement. DESIGN: The Three-Arm Parallel-group Exploratory Trial (NCT04355663). SETTING: Each group underwent different kinds of two months ambulatory therapy (Motor Program Activating Therapy, Vojta's reflex locomotion and Functional Electric Stimulation in Posturally Corrected Position). POPULATION: MS people with moderate disability. METHODS: At baseline and after the program, participants underwent magnetic resonance diffusion tensor imaging (DTI) and clinical assessment. Fractional anisotropy maps obtained from DTI were further analyzed using tract-based spatial statistic exploring the mean values in the whole statistic skeleton. Moreover, additional exploratory analysis in 48 regions of white matter was done. RESULTS: Ninety-two people were recruited. DTI data from 61 people were analyzed. The neurofacilitation (irrespective type of therapy) resulted in significant improvement on the Berg Balance Scale (P=0.0089), mainly driven by the Motor Program Activating Therapy. No statistically significant change in the whole statistic skeleton was observed (only a trend for decrement of fractional anisotropy after Vojta's reflex locomotion). Additional exploratory analysis confirmed significant decrement of fractional anisotropy in the right anterior corona radiata. CONCLUSIONS: Neurofacilitation improved balance without much evidence of white matter integrity changes in people with MS. CLINICAL REHABILITATION IMPACT: The study results point to the importance of neuroproprioceptive "facilitation and inhibition" physical therapy in the management of balance in people with multiple sclerosis; and the potential to induce white matter changes due to the possibility of interfering with the neuronal tactility threshold.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European journal of physical and rehabilitation medicine
ISSN
1973-9087
e-ISSN
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Volume of the periodical
57
Issue of the periodical within the volume
6
Country of publishing house
IT - ITALY
Number of pages
11
Pages from-to
889-899
UT code for WoS article
000734175600005
EID of the result in the Scopus database
2-s2.0-85122024185