Ambulatory neuroproprioceptive facilitation and inhibition physical therapy improves clinical outcomes in multiple sclerosis and modulates serum level of neuroactive steroids: A two-arm parallel-group exploratory trial

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F20%3A43920732" target="_blank" >RIV/00216208:11120/20:43920732 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/20:10417207 RIV/00023761:_____/20:N0000002 RIV/00064203:_____/20:10417207

Result on the web

<a href="https://doi.org/10.3390/life10110267" target="_blank" >https://doi.org/10.3390/life10110267</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/life10110267" target="_blank" >10.3390/life10110267</a>

Result language

angličtina

Original language name

Ambulatory neuroproprioceptive facilitation and inhibition physical therapy improves clinical outcomes in multiple sclerosis and modulates serum level of neuroactive steroids: A two-arm parallel-group exploratory trial

Original language description

Background: Only few studies have monitored the potential of physical activity training and physical therapy to modulate the reaction of the endocrine system. In this study, the effect of neuroproprioceptive facilitation and inhibition physical therapy on clinical outcomes and neuroactive steroids production in people with multiple sclerosis was evaluated. Moreover, we were interested in the factors that influence the treatment effect. Methods: In total, 44 patients with multiple sclerosis were randomly divided into two groups. Each group underwent a different kind of two months ambulatory therapy (Motor program activating therapy and Vojta&apos;s reflex locomotion). During the following two months, participants were asked to continue the autotherapy. Primary (serum level of cortisol, cortisone, 7α-OH-DHEA, 7β-OH-DHEA, 7-oxo-DHEA, DHEA) and secondary (balance, cognition and patient-reported outcomes) outcomes were examined three times (pre, post, and washout assessments). Results: In both groups, there is a decreasing trend of 7-oxo-DHEA concentration in post-assessment and 7β-OH-DHEA in washout versus pre-assessment. A higher impact on neuroactive steroids is visible after Vojta&apos;s reflex locomotion. As for clinical outcomes, the Paced Auditory Serial Addition Test and Multiple Sclerosis Impact Scale significantly improved between post-assessment and washout assessment. The improvement was similar for both treatments. Conclusions: Neuroproprioceptive facilitation and inhibition improved the clinical outcomes and led to non-significant changes in neuroactive steroids. Trial registration (NCT04379193).

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30210 - Clinical neurology

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Life

ISSN

2075-1729

e-ISSN

—

Volume of the periodical

10

Issue of the periodical within the volume

11

Country of publishing house

CH - SWITZERLAND

Number of pages

16

Pages from-to

"Article 267"

UT code for WoS article

000594010900001

EID of the result in the Scopus database

2-s2.0-85094866929