Animal experimental models of ischemic wounds - A review of literature
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F22%3A00082268" target="_blank" >RIV/00023001:_____/22:00082268 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/22:10438897 RIV/00216208:11130/22:10438897
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1111/wrr.12996" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/wrr.12996</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/wrr.12996" target="_blank" >10.1111/wrr.12996</a>
Alternative languages
Result language
angličtina
Original language name
Animal experimental models of ischemic wounds - A review of literature
Original language description
Critical limb ischemia is a serious form of peripheral arterial disease (PAD). The consequences of lower limb ischemia are pain, claudication and chronic non-healing wounds. Patients with diabetes are especially at a high risk for developing non-healing ulcers. The most serious complication is major amputation. For this reason, there is a significant medical requirement to develop new therapies in order to prevent the progression of PAD. For research purposes, it is crucial to find an appropriate model of chronic ischemia to explore the processes of wound healing. According to recently acquired information, rodents are currently the most commonly used animals in these types of studies. The main advantage of using small animals is the low financial cost due to the relatively small demand for food, water and living space. The disadvantage is their anatomy, which is different from that of humans. Larger animals have a more human-like anatomy and physiology, but they require more expense and space for housing. A bipedicle skin flap and its modifications are popular models for ischemic wounds. In order to secure healing through re-epithelisation, as opposed to contraction in rodents, there is a need to remove the panniculus carnosus muscle. Wounds in other experimental animals heal primarily through re-epithelisation. The application of a silicone mesh underneath the flap prevents vascular regrowth in ischemic tissue. There is an ongoing effort to create in vivo diabetic models for chronic ulcer research. This work presents an overview of existing animal models of ischemic wounds.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30212 - Surgery
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Wound repair and regeneration
ISSN
1067-1927
e-ISSN
1524-475X
Volume of the periodical
30
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
268-281
UT code for WoS article
000753235300001
EID of the result in the Scopus database
2-s2.0-85124571374