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Animal experimental models of ischemic wounds - A review of literature

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F22%3A00082268" target="_blank" >RIV/00023001:_____/22:00082268 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11110/22:10438897 RIV/00216208:11130/22:10438897

  • Result on the web

    <a href="https://onlinelibrary.wiley.com/doi/10.1111/wrr.12996" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/wrr.12996</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/wrr.12996" target="_blank" >10.1111/wrr.12996</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Animal experimental models of ischemic wounds - A review of literature

  • Original language description

    Critical limb ischemia is a serious form of peripheral arterial disease (PAD). The consequences of lower limb ischemia are pain, claudication and chronic non-healing wounds. Patients with diabetes are especially at a high risk for developing non-healing ulcers. The most serious complication is major amputation. For this reason, there is a significant medical requirement to develop new therapies in order to prevent the progression of PAD. For research purposes, it is crucial to find an appropriate model of chronic ischemia to explore the processes of wound healing. According to recently acquired information, rodents are currently the most commonly used animals in these types of studies. The main advantage of using small animals is the low financial cost due to the relatively small demand for food, water and living space. The disadvantage is their anatomy, which is different from that of humans. Larger animals have a more human-like anatomy and physiology, but they require more expense and space for housing. A bipedicle skin flap and its modifications are popular models for ischemic wounds. In order to secure healing through re-epithelisation, as opposed to contraction in rodents, there is a need to remove the panniculus carnosus muscle. Wounds in other experimental animals heal primarily through re-epithelisation. The application of a silicone mesh underneath the flap prevents vascular regrowth in ischemic tissue. There is an ongoing effort to create in vivo diabetic models for chronic ulcer research. This work presents an overview of existing animal models of ischemic wounds.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30212 - Surgery

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Wound repair and regeneration

  • ISSN

    1067-1927

  • e-ISSN

    1524-475X

  • Volume of the periodical

    30

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    14

  • Pages from-to

    268-281

  • UT code for WoS article

    000753235300001

  • EID of the result in the Scopus database

    2-s2.0-85124571374