Adiponectin, A-FABP and FGF-19 Levels in Women with Early Diagnosed Gestational Diabetes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F22%3A00082618" target="_blank" >RIV/00023001:_____/22:00082618 - isvavai.cz</a>

Alternative codes found

RIV/00098892:_____/22:10157278 RIV/61989592:15110/22:73614241

Result on the web

<a href="https://www.mdpi.com/2077-0383/11/9/2417" target="_blank" >https://www.mdpi.com/2077-0383/11/9/2417</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/jcm11092417" target="_blank" >10.3390/jcm11092417</a>

Result language

angličtina

Original language name

Adiponectin, A-FABP and FGF-19 Levels in Women with Early Diagnosed Gestational Diabetes

Original language description

Background: Adiponectin, adipocyte fatty acid-binding protein (A-FABP), and fibroblast growth factor-19 (FGF-19) belong to proteins involved in glucose metabolism regulation. The aims of the study were to compare the plasma levels of these proteins in women with early diagnosed gestational diabetes mellitus (GDM) to those in healthy controls and to investigate their changes during pregnancy after early intervention. Methods: The study was undertaken as a case-control study. Early GDM diagnosis was based on repeated fasting plasma glucose ≥5.1 and &lt;7.0 mmol/L during the first trimester of pregnancy and exclusion of overt diabetes. Age-matched controls com-prised healthy pregnant and non-pregnant women. In addition to adipokines, clinical parameters and measures of glucose control were assessed. Results: Women with GDM (n = 23) had significantly lower adiponectin and higher A-FABP levels compared to healthy pregnant (n = 29) or non-pregnant (n = 25) controls, while no significant differences in FGF-19 between the groups were found. The therapeutic intervention shifted adiponectin and A-FABP levels in GDM women towards concentrations of healthy pregnant controls. Adipokines were associated with visceral adiposity and glucose control. Conclusion: Women with GDM showed altered adipokine production even in the first trimester of pregnancy. Early therapeutic intervention not only improved glucose control but also normalized impaired adipokine production. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

<a href="/en/project/NV18-01-00139" target="_blank" >NV18-01-00139: Gestational diabetes mellitus - contribution of entero-insular axis hormones, selected adipokines and gut microbiota to its different phenotypes</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of clinical medicine

ISSN

2077-0383

e-ISSN

2077-0383

Volume of the periodical

11

Issue of the periodical within the volume

9

Country of publishing house

CH - SWITZERLAND

Number of pages

11

Pages from-to

"art. no. 2417"

UT code for WoS article

000799316200001

EID of the result in the Scopus database

2-s2.0-85128782196