Circulating levels of selected adipokines in women with gestational diabetes and type 2 diabetes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F20%3A73601499" target="_blank" >RIV/61989592:15110/20:73601499 - isvavai.cz</a>

Alternative codes found

RIV/00098892:_____/20:N0000055

Result on the web

<a href="https://jab.zsf.jcu.cz/pdfs/jab/2020/02/04.pdf" target="_blank" >https://jab.zsf.jcu.cz/pdfs/jab/2020/02/04.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.32725/jab.2020.007" target="_blank" >10.32725/jab.2020.007</a>

Result language

angličtina

Original language name

Circulating levels of selected adipokines in women with gestational diabetes and type 2 diabetes

Original language description

Backgrounds: Adiponectin, adipocyte-fatty acid binding protein (A-FABP), and Wnt1 inducible signaling pathway protein-1 (WISP-1) are adipokines closely associated with insulin resistance. The aim of the study was to compare their levels in women with gestational diabetes (GDM), type 2 diabetes mellitus (T2DM) and healthy controls and determine their relation to metabolic parameters. Methods: Women with GDM, T2DM and healthy women were included in this cross-sectional study. In addition to adipokines, anthropometric, lipid parameters, markers of insulin resistance and glucose control were assessed in all participants. Results: Compared to healthy controls (n = 35) significantly lower levels of adiponectin were detected in women with GDM (n = 50), whereas in women with T2DM (n = 50) higher levels of A-FABP and WISP-1 and lower levels of adiponectin were found. Women with T2DM had also lower levels of adiponectin and higher levels of A-FABP compared to women with GDM. A-FABP and diponectin were independently associated with levels of triglycerides, HDL-cholesterol and C-peptide insulin resistance index. WISP-1 correlated only with waist circumference. Conclusions: Adverse adipokines production reflecting dysfunctional fat tissue is less presented in women with GDM than in women with T2DM, but more expressed compared to healthy women.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

<a href="/en/project/NV18-01-00139" target="_blank" >NV18-01-00139: Gestational diabetes mellitus - contribution of entero-insular axis hormones, selected adipokines and gut microbiota to its different phenotypes</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Applied Biomedicine

ISSN

1214-021X

e-ISSN

—

Volume of the periodical

18

Issue of the periodical within the volume

2-3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

54-60

UT code for WoS article

000563565100004

EID of the result in the Scopus database

2-s2.0-85090097561