Impact of Endoluminal Radiofrequency Ablation on Immunity in Pancreatic Cancer and Cholangiocarcinoma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F22%3A00082692" target="_blank" >RIV/00023001:_____/22:00082692 - isvavai.cz</a>
Alternative codes found
RIV/00064173:_____/22:43923678 RIV/00098892:_____/22:10157434 RIV/00216208:11120/22:43923678 RIV/61989592:15110/22:73614788
Result on the web
<a href="https://www.mdpi.com/2227-9059/10/6/1331" target="_blank" >https://www.mdpi.com/2227-9059/10/6/1331</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/biomedicines10061331" target="_blank" >10.3390/biomedicines10061331</a>
Alternative languages
Result language
angličtina
Original language name
Impact of Endoluminal Radiofrequency Ablation on Immunity in Pancreatic Cancer and Cholangiocarcinoma
Original language description
Radiofrequency ablation (RFA) is a mini-invasive loco-regional ablation technique that is increasingly being used as a palliative treatment for pancreatic cancer and cholangiocarcinoma. Ablation-triggered immune system stimulation has been proposed as a mechanism behind the systemic effects of RFA. The aim of our study was to investigate the immune response to endoluminal biliary RFA. Peripheral blood samples were collected from patients with pancreatic cancer and cholangiocarcinoma randomised to receive endoluminal biliary radiofrequency ablation + stent (19 patients) or stent only (21 patients). We observed an early increase in IL-6 levels and a delayed increase in CXCL1, CXCL5, and CXCL11 levels as well as an increase in CD8+ and NK cells. However, these changes were not specific to RFA treatment. Explicitly in response to RFA, we observed a delayed increase in serum CXCL1 levels and an early decrease in the number of anti-inflammatory CD206+ blood monocytes. Our study provides the first evidence of endoluminal biliary RFA-based regulation of the systemic immune response in patients with pancreatic cancer and cholangiocarcinoma. These changes were characterised by a general inflammatory response. RFA-specific activation of the adaptive immune system was not confirmed.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30219 - Gastroenterology and hepatology
Result continuities
Project
<a href="/en/project/NV17-30281A" target="_blank" >NV17-30281A: Radiofrequency ablation in therapy of biliary and pancreatic disease</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomedicines
ISSN
2227-9059
e-ISSN
2227-9059
Volume of the periodical
10
Issue of the periodical within the volume
6 June
Country of publishing house
CH - SWITZERLAND
Number of pages
16
Pages from-to
"art. no. 1331"
UT code for WoS article
000816146800001
EID of the result in the Scopus database
2-s2.0-85132124692