Association between SARS-CoV-2 messenger RNA vaccines and lower infection rates in kidney ttansplant recipients a registry-based report
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F22%3A00083315" target="_blank" >RIV/00023001:_____/22:00083315 - isvavai.cz</a>
Result on the web
<a href="https://www.acpjournals.org/doi/epdf/10.7326/M21-2973" target="_blank" >https://www.acpjournals.org/doi/epdf/10.7326/M21-2973</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.7326/M21-2973" target="_blank" >10.7326/M21-2973</a>
Alternative languages
Result language
angličtina
Original language name
Association between SARS-CoV-2 messenger RNA vaccines and lower infection rates in kidney ttansplant recipients a registry-based report
Original language description
Background: The real-world protection provided by SARS-CoV-2 messenger RNA (mRNA) vaccines to kidney transplant recipients (KTRs) remains uncertain. Objective: To study the association between mRNA vaccination and SARS-CoV-2 infection rate in KTRs. Design: Retrospective observational cohort study. Setting: The Czech Republic (17 February to 16 May 2021). Patients: 2101 KTRs followed in the Department of Nephrology at the Institute for Clinical and Experimental Medicine. Measurements: Positive result for SARS-CoV-2 on polymerase chain reaction test and vaccination status of KTRs. Results: The incidence rate in the vaccinated group was 0.474 per 1000 person-days (33 cases in 69 672 days at risk). The incidence rate in the unvaccinated group was 1.370 per 1000 person-days (79 cases in 57 658 days at risk). The unadjusted incidence rate ratio (IRR; incidence rate of vaccinated/incidence rate of unvaccinated) for KTRs was 0.346 (95% CI, 0.227 to 0.514). The multivariable adjusted IRR for KTRs was 0.544 (CI, 0.324 to 0.876). Limitation: Retrospective observational design, uneven follow-up of patient groups, and different exposition to SARS-CoV-2 stemming from strong temporal trends and differences in clinical and probably behavioral characteristics. Conclusion: Vaccination of KTRs is associated with lower risk for SARS-CoV-2 infection.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30217 - Urology and nephrology
Result continuities
Project
<a href="/en/project/NU22-C-126" target="_blank" >NU22-C-126: Aspects of immune response and efficacy of booster dose of SARS-CoV-2 mRNA vaccine in kidney transplant recipients</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Annals of internal medicine
ISSN
0003-4819
e-ISSN
1539-3704
Volume of the periodical
175
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
961-968
UT code for WoS article
000830679100014
EID of the result in the Scopus database
2-s2.0-85134720817